Publications by authors named "Sabrina Di Monaco"
Deletion of the genes, encoding protocatechuate 3,4-dioxygenase in RHA1, gives a gene deletion strain still able to grow on protocatechuic acid as the sole carbon source, indicating a second degradation pathway for protocatechuic acid. Metabolite analysis of wild-type RHA1 grown on medium containing vanillin or protocatechuic acid indicated the formation of hydroxyquinol (benzene-1,2,4-triol) as a downstream product. Gene cluster ro01857-ro01860 in RHA1 contains genes encoding hydroxyquinol 1,2-dioxygenase and maleylacetate reductase for degradation of hydroxyquinol but also putative mono-oxygenase (ro01860) and putative decarboxylase (ro01859) genes, and a similar gene cluster is found in the genome of lignin-degrading species.
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- A new catalytic system using a cobalt-diphosphine complex paired with a Lewis acid like AlMe has been developed to facilitate the hydrocarbofunctionalization of alkynes with Lewis basic and electron-deficient compounds, enabling selective activation of C-H bonds.
- This system is advantageous over existing nickel-based equivalents due to its use of cheaper, stable precatalysts and its ability to achieve specific C-H activation at different sites on pyridine and imidazo[1,2-]pyridine compounds.
- Mechanistic studies indicate that the reaction's slowest step involves breaking a specific C-H bond through a ligand-to-ligand hydrogen transfer process, creating a cobalt complex that leads to the desired product.