Publications by authors named "Sabrina Dewes"
Background: Approximately 20-40% of patients with prostate cancer (PC) who undergo radical prostatectomy (RP) experience relapse, with the majority of these cases developing pelvic lymph node (LN) metastases. Taking new data from the prostate-specific membrane antigen (PSMA) positron emission tomography (PET) era into account, the Radiation Therapy Oncology Group (RTOG) 2009 contouring guideline for the pelvic LNs from 2009 was updated by the NRG Oncology group in 2020 (NRG 2020).
Objective: To evaluate and validate the updated NRG 2020 guideline with our established LN atlas.
Introduction: Prostate-specific membrane antigen-positron emission tomography-(PSMA-PET) imaging facilitates dose-escalated salvage radiotherapy (DE-SRT) with simultaneous-integrated boost (SIB) for PET-positive lesions in patients with prostate cancer (PC). Therefore, we aimed to compare toxicity rates of DE-SRT with SIB to conventional SRT (C-SRT) without SIB and to report outcome.
Materials And Methods: We evaluated 199 patients who were treated with SRT between June 2014 and June 2020.
Background: Positron emission tomography-(PET) has evolved as a powerful tool to guide treatment for prostate cancer (PC). The aim of this survey was to evaluate the acceptance and use of PET-especially with prostate-specific membrane antigen (PSMA) targeting tracers-in clinical routine for radiotherapy (RT) and the impact on target volume definition and dose prescription.
Methods: We developed an online survey, which we distributed via e-mail to members of the German Society of Radiation Oncology (DEGRO).
Background: Emerging moderately hypofractionated and ultra-hypofractionated schemes for radiotherapy (RT) of prostate cancer (PC) have resulted in various treatment options. The aim of this survey was to evaluate recent patterns of care of German-speaking radiation oncologists for RT of PC.
Methods: We developed an online survey which we distributed via e‑mail to all registered members of the German Society of Radiation Oncology (DEGRO).
Background: Local radiation therapy of metastases in prostate cancer patients has become increasingly important in recent years. In order to improve the evaluation of the outcome, we have studied oligometastatic prostate cancer patients who were treated with stereotactic radiation therapy.
Patients And Methods: 24 patients with a total of 30 bone metastases were included in the study.
Background: Ga-PSMA-PET imaging is a novel promising diagnostic tool to locate early biochemical failure after radical prostatectomy (RP) in prostate cancer (PC) patients. Exact knowledge of the relapse location may result in changes of the therapy concept aside from changes to the TNM stage. To gain data for this approach, we evaluated PC patients receiving Ga-PSMA-PET imaging before salvage radiotherapy (RT).
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- - The study evaluated how effectively a specific PET/CT scan, using a Ga-PSMA ligand, detects recurrent prostate cancer in 118 patients who had previously undergone external-beam radiotherapy or brachytherapy, with a focus on biochemical recurrence defined by the Phoenix criteria.
- - Out of the patients studied, 90.7% showed signs of tumor recurrence on the PET/CT scans, with detection rates varying based on PSA levels and showing a higher detection rate in patients receiving androgen-deprivation therapy (ADT).
- - The scan identified both local and distant recurrences, demonstrating significant associations between the scan results (SUV values) and both PSA levels and ADT status, indicating the PET/CT's utility in guiding subsequent treatment decisions
Background: Prostate cancer (PC) is one of the most commonly treated cancer entities with radiation therapy (RT). Risk group-adapted treatment and avoidance of unnecessary toxicities relies primarily on accurate tumor staging. Thus, the introduction of prostate-specific membrane antigen (PSMA) in diagnosis and treatment of PC is a highly interesting development in radiation oncology of urologic tumors.
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