Publications by authors named "Sabrina Denzinger"
Pharmacol Res
December 2024
Article Synopsis
- Impaired calcium (Ca) handling in heart cells is a key feature of heart failure (HF), leading to issues like weakened heart contractions and irregular heartbeats.
- The study used transgenic mice with a mutation affecting a calcium regulator (phospholamban) to understand how defects in calcium cycling contribute to HF, noting that these mice experience severe and fast-progressing heart failure.
- Early treatment aimed at correcting calcium cycling using Raf kinase inhibitor protein (RKIP) was found to delay heart cell damage and improve overall health of the mice, indicating that addressing Ca dynamics early on could be crucial for preventing further complications in heart failure.
Article Synopsis
- The study reveals that overexpressing RKIP can enhance heart contractility without causing structural damage, which is typically a concern in heart failure treatments.
- This increase in contractility is linked to the β1-adrenoceptor while also activating the β2-adrenoceptor, providing a unique mechanism of tolerance.
- RKIP levels rise in heart failure cases, indicating its potential adaptive role, and transferring the Pebp1 gene shows promise as a new treatment strategy.
