Otologic safety of intratympanic N-acetylcysteine in an animal model.

Objective: N-acetylcysteine (NAC) is an anti-oxidant and mucolytic effective against bacterial biofilms, making it useful in the treatment of chronically discharging ears that are unresponsive to traditional treatment methods. The objective of this study was to evaluate the otologic safety of intratympanic NAC combined with Ciprodex® in an animal model.

Methods: Baseline distortion product otoacoustic emissions (DPOAE) and auditory brainstem response (ABR) measurements were performed for both ears on thirteen guinea pigs from the animal care research facilities of the McGill University Health Center.

Flavonoids-Rich Plant Extracts Against Infection as Prevention to Gastric Cancer.

Gastric cancer is the fifth most common and fourth type to cause the highest mortality rates worldwide. The leading cause is related to () infection. Unfortunately, current treatments have low success rates, highlighting the need for alternative treatments against carcinogenic agents, specifically .