Publications by authors named "Sabrina Collias"
Article Synopsis
- The text discusses a new mouse model called TIRFA, designed to improve the study of AAV-mediated gene therapy by eliminating the AAV receptor in mouse cells, making them less efficient for AAV infection.
- The TIRFA model shows better AAV transduction in human liver cells and other human-derived tissues compared to traditional humanized mice.
- This advancement helps researchers better predict AAV gene transfer efficiency and investigate AAV vector biology, ultimately aiding in clinical translation of gene therapies.
