Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability.

Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The invasiveness and the rapid progression that characterize GBM negatively impact patients' survival. Temozolomide (TMZ) is currently considered the first-choice chemotherapeutic agent.

CT colonography: patient tolerance of laxative free fecal tagging regimen versus traditional cathartic cleansing.

Purpose: The aim of our prospective study was to compare patient tolerance of laxative free fecal tagging regimen (LFT) versus traditional cathartic cleansing (TC).

Materials And Methods: 264 patients, at average risk for development of colorectal cancer (105 men and 159 women; mean age 62 years ± 5 SD), underwent 32 rows CT colonography. Patients were alternatively placed into 2 study groups: Group 1 (n = 132) followed TC and Group 2 (n = 132) LFT.

Mapping the main Leishmania phlebotomine vector in the endemic focus of the Mt. Vesuvius in southern Italy.

Geographical information systems and remote sensing were used to analyze the distribution of the Leishmania infantum-Phlebotomus perniciosus parasite-vector system in relation to environmental features of two opposite sides (coastal and Apennine) of Mt. Vesuvius, an area of intense transmission of human and canine leishmaniasis in southern Italy. Weekly phlebotomine collections were carried out during two consecutive warm seasons (2004- 2005) in 24 and 25 sites of the coastal and Apennine sides, respectively.

A survey of fleas on dogs in southern Italy.

A survey aimed at studying the presence and distribution of fleas on dogs was conducted in an area of southern Italy. Between February 2005 and 2006, dogs were examined for fleas at four private veterinary clinics, with a twice-weekly frequency. Fleas were detected on 246 (17.

Canine faecal contamination and parasitic risk in the city of Naples (southern Italy).

Background: Dogs are associated with more than 60 zoonotic diseases among which, parasitosis and, in particular, helminthosis, can pose serious public-health concerns worldwide. Many canine gastrointestinal parasites eliminate their dispersion elements (eggs, larvae, oocysts) by the faecal route. The quantity of canine faeces deposited on public and private property in cities worldwide is both a perennial nuisance and an important health issue.