Synopsis of recent research by authors named "Sabrina Arena"
- Sabrina Arena's recent research focuses on advancing therapeutic strategies for colorectal cancer (CRC) by identifying genetic vulnerabilities linked to homologous recombination deficiency and metabolic adaptations that contribute to treatment resistance.
- Key findings include the development of the HRDirect tool for predicting homologous recombination deficiency, uncovering MCT1-dependent lactate recycling as a metabolic vulnerability in anti-EGFR therapy-resistant CRC, and exploring combinatorial immunotherapy targeting HER2 and carcinoembryonic antigen in HER2-amplified CRC cases.
- Arena's studies also highlight the potential of exploiting the DNA damage response mechanisms and utilizing patient-derived models for personalized treatment approaches, thereby contributing to a better understanding of the resistance mechanisms and enhancing clinical outcomes in CRC patients.
