Publications by authors named "Sabrina A Mendez"
Article Synopsis
- The prostate cancer tumor microenvironment (TME) contains various cell types, including macrophages that can be M1-like (anti-tumor) or M2-like (pro-tumor), with M2 macrophages playing a key role in efferocytosis, the process of engulfing dying cells.
- Research suggests that targeting MerTK, a receptor involved in efferocytosis, may hinder tumor growth and enhance anti-tumor immune responses.
- Initial findings from experiments show that M2 macrophages have a higher capacity for efferocytosis of prostate cancer cells and that inhibiting MerTK reduces this process, promoting a shift toward a more anti-tumor immune profile in a mouse model.
