Publications by authors named "Saboor Saeed"
Background: The mechanisms underlying esketamine's therapeutic effects remain elusive. The study aimed to explore the impact of single esketamine treatment on LPS-induced adolescent depressive-like behaviors and the role of Nrf2 regulated neuroinflammatory response in esketamine-produced rapid antidepressant efficacy.
Methods: Adolescent male C57BL/6J mice were randomly assigned to three groups: control, LPS, and LPS + esketamine (15 mg/kg, i.
Article Synopsis
- Epidemiological research links early sexual intercourse to a higher risk of intentional self-harm, but the exact reasons, especially the influence of mental health disorders, are still unclear.
- This study used genetic data from the UK Biobank and FinnGen Biobank to examine the causal relationship between the age of first sexual intercourse and intentional self-harm, also analyzing how conditions like major depressive disorder and schizophrenia mediate this relationship.
- Results show that early sexual intercourse significantly increases the risk of self-harm, with major depressive disorder and schizophrenia accounting for nearly half of this increased risk, highlighting the importance of mental health support for adolescents engaging in early sexual activities.
Background: Despite sharing common pathophysiological risk factors, the relationship between gallstones and depression requires further evidence for a clearer understanding. This study combines the National Health and Nutrition Examination Survey 2017 - 2020 observational data and Mendelian randomization (MR) analysis to shed light on the potential correlation between these conditions.
Methods: By analyzing the National Health and Nutrition Examination Survey 2017 - 2020 data through weighted multivariable-adjusted logistic regression, we examined the association between depression and gallstone risk.
Background: Impaired mitochondrial dynamics have been identified as a significant contributing factor to reduced neurogenesis under pathological conditions. However, the relationship among mitochondrial dynamics, neurogenesis, and spatial memory during normal development remains unclear. This study aims to elucidate the role of mitophagy in spatial memory mediated by neurogenesis during development.
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- The coexistence of Crohn's disease and acute appendicitis is uncommon, presenting challenges in treatment due to differing recommended approaches for each condition.
- A 17-year-old boy with Crohn's disease experienced symptoms of appendicitis, and after confirmation through ultrasound, he underwent endoscopic retrograde appendicitis therapy (ERAT) rather than a traditional appendectomy.
- The ERAT procedure was successful, providing immediate pain relief and preventing further abdominal attacks over an 18-month follow-up, indicating it as a safe alternative treatment in patients with both conditions.
Background: Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2, is a rare but serious complication of SARS-CoV-2 infection in children that typically occurs 2-6 weeks after SARS-CoV-2 infection. The pathophysiology of MIS-C is unknown. MIS-C, first recognized in April 2020, is characterized by fever, systemic inflammation, and multi-system organ involvement.
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