Real-World Implications of Updated Surviving Sepsis Campaign Antibiotic Timing Recommendations.

Objective: To evaluate real-world implications of updated Surviving Sepsis Campaign (SSC) recommendations for antibiotic timing.

Design: Retrospective cohort study.

Setting: Twelve hospitals in the Southeastern United States between 2017 and 2021.

A Quantitative Study of Decision Thresholds for Initiation of Antibiotics in Suspected Sepsis.

Background: Clinicians' decision thresholds for initiating antibiotics in patients with suspected sepsis have not been quantified. We aimed to define an average threshold of infection likelihood at which clinicians initiate antibiotics when treating a patient with suspected infection and to evaluate the influence of severity of illness and clinician-related factors on the threshold.

Design: This was a prospective survey of 153 clinicians responding to 8 clinical vignettes constructed from real-world data from 3 health care systems in the United States.

Developmental origin of limb size variation in lizards.

In many respects, reptile hatchlings are fully functional, albeit miniature, adults. This means that the adult morphology must emerge during embryonic development. This insight emphasizes the connection between the mechanisms that generate phenotypic variation during embryonic development and the action of selection on post-hatching individuals.