Evaluation of nutritional and techno-functional aspects of black soldier fly high-protein extracts in different developmental stages.

The global need for sustainable protein sources has contributed to the search for alternatives to conventional livestock and aquaculture feed. The black soldier fly (BSF) is a potential option for sustainable protein production due to its ability to convert organic waste into high-value biomass efficiently. To maximise its feed, food application, and resource recovery potential, the nutritional composition and techno-functional properties must be analysed in different developmental stages.

Prevalence and risk factors for non-secure housing in inpatients of mental health hospitals: findings from a survey in North rhine - Westphalia, Germany.

Background: Little is known about uptake of mental healthcare services by homeless people and even less is known about those living in precarious housing. The "WohnLos" study determined the prevalence of non-secure housing (defined as homelessness or precarious housing) among inpatients of two groups of public mental health hospitals in the state of North Rhine-Westphalia (NRW), Germany.

Methods: We conducted a questionnaire survey in the two hospital groups, which provide in- and out-patient mental healthcare for a population of about ten million people.

First Measurement of the Neutron-Emission Probability with a Surrogate Reaction in Inverse Kinematics at a Heavy-Ion Storage Ring.

Neutron-induced reaction cross sections of short-lived nuclei are imperative to understand the origin of heavy elements in stellar nucleosynthesis and for societal applications, but their measurement is extremely complicated due to the radioactivity of the targets involved. One way of overcoming this issue is to combine surrogate reactions with the unique possibilities offered by heavy-ion storage rings. In this work, we describe the first surrogate-reaction experiment in inverse kinematics, which we successfully conducted at the Experimental Storage Ring (ESR) of the GSI/FAIR facility, using the ^{208}Pb(p,p^{'}) reaction as a surrogate for neutron capture on ^{207}Pb.

Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth.

Neonates primarily rely on innate immune defense, yet their inflammatory responses are usually restricted compared to adults. This is controversially interpreted as a sign of immaturity or essential programming, increasing or decreasing the risk of sepsis, respectively. Here, combined transcriptomic, metabolic, and immunological studies in monocytes of healthy individuals reveal an inverse ontogenetic shift in metabolic pathway activities with increasing age.

Neural correlates of uncertainty processing in psychosis spectrum disorder.

Psychotic beliefs are typically held with high certainty. Altered computation of uncertainty about a belief and about environmental dynamics may be an underlying mechanism of psychotic symptoms. We set out to shed light on behavioural and neural correlates of uncertainty processing and how it drives belief updating in psychosis.

Factors Affecting Gastroenterologists' Fear When Performing Endoscopies during the COVID Pandemic: Results of a US National Survey.

Objectives: The coronavirus disease 2019 (COVID-19) pandemic affected the practice of gastroenterology. Endoscopic procedures are aerosolizing procedures that carry the risk of COVID-19 transmission. Our national survey examined factors affecting gastroenterologists' fear of contracting COVID-19 during endoscopy.

Prediction of carbon nanostructure mechanical properties and the role of defects using machine learning.

Graphene-based nanostructures hold immense potential as strong and lightweight materials, however, their mechanical properties such as modulus and strength are difficult to fully exploit due to challenges in atomic-scale engineering. This study presents a database of over 2,000 pristine and defective nanoscale CNT bundles and other graphitic assemblies, inspired by microscopy, with associated stress-strain curves from reactive molecular dynamics (MD) simulations using the reactive INTERFACE force field (IFF-R). These 3D structures, containing up to 80,000 atoms, enable detailed analyses of structure-stiffness-failure relationships.

Outcomes of anatomic total shoulder arthroplasty: evaluation of implant-related, radiographic, and demographic factors influencing durability and revision rates.

Purpose: To evaluate the impact of implant-associated and radiographic factors on survival rates and revisions of total shoulder arthroplasty (TSA) in patients with primary osteoarthritis (OA).

Methods: This retrospective study included 68 patients who underwent TSA for primary OA at a single institution between 2008 and 2015, with a minimum follow-up of 60 months. Patients with prior shoulder surgeries, perioperative infections, or revisions within 12 months postoperatively were excluded.

Probing New Bosons and Nuclear Structure with Ytterbium Isotope Shifts.

In this Letter, we present mass-ratio measurements on highly charged Yb^{42+} ions with a precision of 4×10^{-12} and isotope-shift measurements on Yb^{+} on the ^{2}S_{1/2}→^{2}D_{5/2} and ^{2}S_{1/2}→^{2}F_{7/2} transitions with a precision of 4×10^{-9} for the isotopes ^{168,170,172,174,176}Yb. We present a new method that allows us to extract higher-order changes in the nuclear charge distribution along the Yb isotope chain, benchmarking ab initio nuclear structure calculations. Additionally, we perform a King plot analysis to set bounds on a fifth force in the keV/c^{2} to MeV/c^{2} range coupling to electrons and neutrons.

Proteomic insights into survival strategies of Escherichia coli in perchlorate-rich Martian brines.

Brines, potentially formed by the deliquescence and freezing point depression of highly hygroscopic salts, such as perchlorates (ClO), may allow for the spatial and temporal stability of liquid water on present-day Mars. It is therefore of great interest to explore the microbial habitability of Martian brines, for which our current understanding is, however, still limited. Putative microbes growing in the perchlorate-rich Martian regolith may be harmed due to the induction of various stressors including osmotic, chaotropic, and oxidative stress.

Artificial intelligence in neurovascular decision-making: a comparative analysis of ChatGPT-4 and multidisciplinary expert recommendations for unruptured intracranial aneurysms.

In the multidisciplinary treatment of cerebrovascular diseases, specialists from different disciplines strive to develop patient-specific treatment recommendations. ChatGPT is a natural language processing chatbot with increasing applicability in medical practice. This study evaluates ChatGPT's ability to provide treatment recommendations for patients with unruptured intracranial aneurysms (UIA).

Energy transfer booster: how a leaving group controls the excited state pathway within a caging BASHY-BODIPY dyad.

Photocages are powerful tools for spatiotemporal control of molecule release or biological activity. However, many photocages are unsuitable for biological experiments since they are mostly activated by harmful ultraviolet (UV) light and often lack a sufficient optical readout. Thus, there is a high demand for near infrared (NIR) and/or two-photon activatable photocages with a characteristic readout.

Mosquito host background influences microbiome-ZIKV interactions in field and laboratory-reared .

The mosquito microbiota represents an intricate assemblage of microorganisms, comprising bacteria, fungi, viruses, and protozoa. Factors modulating microbiome abundance and composition include host genetic background, environmental parameters, and pathogen exposure. Conversely, the microbiome profoundly influences pathogen infection of the mosquito host and thus harbours considerable potential to impact the transmission of vector-borne diseases.

Diaphragmatic Ultrasound in Adults: Image Acquisition and Interpretation.

Diaphragm dysfunction is a widely recognized concern across numerous medical specialties and clinical settings. Timely and accurate assessment of the diaphragm is vital not only in critically ill patients, where it has a role in weaning from mechanical ventilation and respiratory outcomes, but also in the perioperative arena as a diagnostic tool to detect phrenic nerve function. Diaphragmatic assessment has traditionally utilized fluoroscopy and nerve studies that are time-consuming, costly, and non-portable.

Observation of Λ_{c}^{+}→Λa_{0}(980)^{+} and Evidence for Σ(1380)^{+} in Λ_{c}^{+}→Λπ^{+}η.

Based on 6.1  fb^{-1} of e^{+}e^{-} annihilation data collected at center-of-mass energies from 4.600 to 4.

Test of Lepton Universality and Measurement of the Form Factors of D^{0}→K^{*}(892)^{-}μ^{+}ν_{μ}.

One of the main goals of studying semileptonic decays in flavor physics is to gain a better understanding of hadronic transitions in the nonperturbative region of Quantum Chromodynamics. This involves measuring Cabibbo-Kobayashi-Maskawa matrix elements, understanding form factors, and comparing them with theoretical predictions. We report a first study of the semileptonic decay D^{0}→K^{-}π^{0}μ^{+}ν_{μ} by analyzing an e^{+}e^{-} annihilation data sample of 7.

Study of D_{s}^{+}→f_{0}(980)ρ^{+} and ϕπ^{+} Decays through D_{s}^{+}→π^{+}π^{+}π^{-}π^{0}.

We perform the first amplitude analysis of D_{s}^{+}→π^{+}π^{+}π^{-}π^{0} decays based on data samples of electron-positron collisions recorded with the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, corresponding to an integrated luminosity of 7.

Identification and external validation of a problem cannabis risk network.

Background: Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural mechanisms underlying risk for problem-level use is critical to facilitate the development of more effective prevention and treatment approaches.

Methods: The current study applied a whole-brain, data-driven, machine-learning approach to identify neural features predictive of problem-level cannabis use in a non-clinical sample of college students (n=191, 58% female) based on reward task functional connectivity data.

Maladaptive mother-child interactions in mothers with remitted major depression are associated with blunted amygdala responses to child affective facial expressions.

Background: Maternal depression is associated with difficulties in understanding and adequately responding to children's emotional signals. Consequently, the interaction between mother and child is often disturbed. However, little is known about the neural correlates of these parenting difficulties.

Probability Density Analysis Reveals Substantial Differences Between the Dinitrogen and Acetylene Triple Bonds.

In earlier publications, it was shown that the electron positions maximizing the probability density resemble the Lewis structures for most small molecules. While this holds for the triple bond in acetylene, this is not the case for the triple bond in dinitrogen. Because of recent advances in studying the topology of wave functions, this peculiar case is revisited.

Problems and Barriers Related to the Use of AI-Based Clinical Decision Support Systems: Interview Study.

Background: Digitalization is currently revolutionizing health care worldwide. A promising technology in this context is artificial intelligence (AI). The application of AI can support health care providers in their daily work in various ways.

Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence.

Laboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular underpinnings are not well understood.

Anhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study.

Anhedonia, i.e., the loss of pleasure or lack of reactivity to reward, is a core symptom of major psychiatric conditions.

User-Oriented Requirements for Artificial Intelligence-Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project.

Background: Artificial intelligence (AI)-based clinical decision support systems (CDSS) have been developed for several diseases. However, despite the potential to improve the quality of care and thereby positively impact patient-relevant outcomes, the majority of AI-based CDSS have not been adopted in standard care. Possible reasons for this include barriers in the implementation and a nonuser-oriented development approach, resulting in reduced user acceptance.