Publications by authors named "Sabine Schwamberger"
Purpose: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG-TSL-DOX) combined with local hyperthermia (HT) was evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma [STS]). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported.
View Article and Find Full Text PDFTritrichomonas muris is occasionally identified during routine fecal screening of laboratory mice. Frequently, entire racks are affected, and because no effective treatment is available, culling of affected mice and rederivation by embryo transfer have been suggested. The current study evaluated whether treatment with ronidazole, a nitroimidazole efficacious against T.
View Article and Find Full Text PDFArticle Synopsis
- HLA-haploidentical stem cell transplantation can be a viable option for patients without a matched donor, but it still has risks like graft rejection and GvHD, leading to high mortality.
- Researchers conducted a study using dogs as a model to enhance the protocol for haploidentical transplantation by introducing CD6-depleted peripheral blood stem cells, potentially promoting immune tolerance.
- Though the CD6-depleted cells didn't fully prevent GvHD, their administration after unmodified bone marrow may improve engraftment and chimerism, particularly with certain preconditioning techniques; further exploration is needed to refine clinical practices.
Article Synopsis
- Donor lymphocyte transfusions (DLT) can effectively treat leukemia after stem cell transplants but pose a risk of graft-vs-host disease (GVHD), especially when administered shortly after transplantation.
- In a study with DLA-haploidentical dogs receiving CD6-depleted bone marrow, early DLT (on days 3, 7, and 14) led to severe GVHD, whereas DLT given at day 20 was tolerated in some cases.
- The research shows that using CD6 depletion for T-cell reduction can promote graft-vs-host tolerance while still allowing for successful engraftment of bone marrow.