Publications by authors named "Sabine Kind"
Article Synopsis
- A fungal pathogen affecting low-input apple production has become more widespread in Europe over the past 15 years, yet little is known about its biology and ability to cause disease.
- This study focused on strain DC1_JKI from Germany, which was sequenced to achieve a comprehensive genome assembly, revealing a mating-type locus identified as MAT1-2.
- Analysis across European and Asian samples showed that only MAT1-2 was present in European samples, potentially explaining the absence of the sexual reproduction form of the pathogen in European apple orchards.
Article Synopsis
- The order of rust fungi includes over 7,000 species that significantly affect agriculture, horticulture, forestry, and ecosystems.
- Phakopsora pachyrhizi, the fungus responsible for Asian soybean rust disease, is a prime example of this impact and has a complex genome that has been challenging to assemble accurately.
- Researchers sequenced three genomes of P. pachyrhizi, revealing a size of up to 1.25 Gb and a high transposable element content (~93%), demonstrating the role of these elements in host adaptation, stress responses, and genetic variability.
Article Synopsis
- Pancreatic cancer is linked to malnutrition and weight loss, prompting the use of nutritional interventions alongside standard treatments.
- A systematic review analyzed randomized controlled trials (RCTs) focusing on the effects of various nutritional interventions—like parenteral, enteral nutrition, and dietary supplements—on cachexia and malnutrition in pancreatic cancer patients.
- The review found that enteral nutrition had benefits like reduced hospital stay and complications, while omega-3 fatty acid supplements improved body weight and lean mass, making them preferable options in managing nutritional health for these patients.
Pathogen-derived cytokinins (CKs) have been recognized as important virulence factor in several host-pathogen interactions and it was demonstrated multiple times that phytopathogenic fungi form CKs via the tRNA degradation pathway. In contrast to previous studies, the focus of this study is on the second step of CK formation and CK degradation to improve our understanding of the biosynthesis in fungi on the one hand, and to understand CK contribution to the infection process of Claviceps purpurea on the other hand. The ergot fungus Claviceps purpurea is a biotrophic phytopathogen with a broad host range including economically important crops causing harvest intoxication upon infection.
View Article and Find Full Text PDFTo investigate its susceptibility to ergot infection, we inoculated Brachypodium distachyon with Claviceps purpurea and compared the infection symptoms with those on rye (Secale cereale). We showed that, after inoculation of Brachypodium with Claviceps, the same disease symptoms occurred in comparable temporal and spatial patterns to those on rye. The infection rate of Claviceps on this host was reduced compared with rye, but the disease could be surveyed by fungal genomic DNA quantification.
View Article and Find Full Text PDFBackground: The economically important Ergot fungus Claviceps purpurea is an interesting biotrophic model system because of its strict organ specificity (grass ovaries) and the lack of any detectable plant defense reactions. Though several virulence factors were identified, the exact infection mechanisms are unknown, e.g.
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- Junction-mediating and regulatory protein (JMY) is known for its role as a transcriptional co-factor in the p53-response to DNA damage, but recent studies reveal its significant function in cytoskeleton remodeling and actin assembly.
- The C-terminus of JMY features a VCA-module typical of Arp2/3 complex activators and includes WH2 domains, allowing it to facilitate actin assembly independently of Arp2/3.
- Research identified new interaction partners for JMY and showed that it orchestrates vesicular trafficking in the trans-Golgi region and ER-membrane contact sites, which differs from other known activators like WHAMM or WASH.