Synopsis of recent research by authors named "Sabine Heinen"
- Sabine Heinen's recent research focuses on understanding the mechanisms behind CRISPR-Cas9 double-strand break profiles and their impact on gene editing precision.
- In her study published in *Nat Biotechnol*, she introduced BreakTag, a novel method for profiling Cas9-induced DNA breaks, which provides insights into the determinants of Cas9 incision types.
- The research involved assessing cleavage at over 150,000 endogenous sites, revealing critical factors influencing both on-target and off-target editing outcomes by analyzing approximately 3,500 single guide RNAs.
