Data Fusion to Convert Drug Consumption Quantities into Defined Daily Doses.

Analysis of consumptions has proved a misuse of antibiotics, despite the existence of national requirements. To be able to compute drugs consumption quantities of highly heterogeneous drugs expressed in various doses units, the World Health Organization has defined a defined daily dose. A methodology has been also defined from previous work to compute manually the drugs consumptions in daily defined dose.

Initiation of rilpivirine, tenofovir and emtricitabine (RPV/TDF/FTC) regimen in 363 patients with virological vigilance assessment in 'real life'.

Objectives: To study the single-tablet regimen (STR) combination rilpivirine/tenofovir/emtricitabine (RPV/TDF/FTC) as soon as it became available. We describe a 14 month follow-up in a real clinical setting with a focus on resistance to RPV/TDF/FTC and polymorphisms associated with these drugs.

Methods: We estimated drug resistance at STR baseline by combining all available resistance tests, resulting in a cumulative virtual genotype.