In vitro, ex vivo, instrumental and clinical evaluation of a topical cream on the signs of periorbital ageing.

Objective: Periorbital skin ageing signs are multidimensional, highly visible and a concern for many. We evaluated the potential efficacy of an eye cream to diminish these signs.

Methods: Biological markers associated with ageing, barrier function and homeostasis were analysed in vitro to determine the effects of topically applied eye cream, compared to those of a placebo using human skin tissue models and/or explants.

In a Preliminary Study on Human Subjects, a Cosmetic Cream Containing a Plant Extract Induces Similar Anti-Aging Effects to a Retinol-Containing Cream.

Retinoids are the most effective anti-aging ingredients. Yet, their use can result in adverse reactions. Even bakuchiol, a natural functional analog, can lead to contact dermatitis.

Skin surface hydration decreases rapidly during long distance flights.

Introduction: Dehydration of the stratum corneum leads to sensations and symptoms of 'dry skin' such as skin tightness and itchiness. As these complaints are frequently experienced by airline travellers, the aim of this study was to investigate the changes in skin surface hydration during long distance flights.

Methods: The study was performed on four healthy Caucasian, and on four Japanese women aged 29-39 years, travelling on long distance flights.

Variations of skin biophysical properties after recreational swimming.

Background/purpose: Sensations of itching and skin tightness are frequently reported after recreational swimming in pool water. Our objective was to measure the potential changes occurring at the skin surface under such conditions.

Methods: Nine women participated in this study, which consisted of two periods.

Influence of skin colour on the detection of cutaneous erythema and tanning phenomena using reflectance spectrophotometry.

Background/purpose: This research aims at assessing the influence of baseline skin colour on the ability of reflectance spectrophotometry to detect cutaneous erythema induced by a low concentration of methyl nicotinate (2.5 mM) (first objective), and to detect tanning induced by ultraviolet rays (UVA+UVB) at infra-erythemal doses (second objective).

Methods: Two independent studies were conducted to reach their respective objectives, on 27 women for the first study and on 12 women for the second study.

Effect of hormonal replacement therapy on skin biophysical properties of menopausal women.

Background/purpose: Hormonal replacement therapy (HRT) has been shown in the past to influence well being as well as several somatic features in menopausal women. The aim of this analysis was to study the effect of HRT on various biophysical properties of the skin of menopausal women. Two sub-samples were built to test the effect (1) of 'short-term' HRT in recently menopausal women (n=15), and (2) the effect of 'medium- and long-term' HRT in menopausal women (n=78).