A randomized trial of tacrolimus versus tacrolimus and prednisone for the maintenance of disease remission in noninfectious uveitis.

Purpose: To compare tacrolimus monotherapy with tacrolimus and prednisone therapy for the maintenance of disease remission in subjects with noninfectious posterior segment intraocular inflammation (PSII).

Design: Randomized, controlled, phase 2b, open-label, dual-center noninferiority trial.

Participants: Fifty-eight patients with sight-threatening PSII.

Tubulointerstitial nephritis and uveitis in siblings.

Purpose: To report on the occurrence of tubulointerstitial nephritis and uveitis (TINU) and HLA typing in two siblings.

Design: Retrospective case study.

Methods: HLA typing from two siblings with TINU syndrome and their parents was performed on DNA from peripheral blood mononuclear cells (PBMC).

Retinal pigment epithelial tear after subretinal rtpa and intravitreal air for the displacement of a large submacular hemorrhage.

Purpose: The authors report a case of retinal pigment epithelial (RPE) tear following pars plana vitrectomy (PPV), subretinal recombinant tissue plasminogen activator (rt-PA), and intravitreal gas administration for the displacement of large submacular hemorrhage.

Methods: A patient with a large submacular hemorrhage secondary to neovascular age-related macular degeneration (AMD) received a subretinal rt-PA injection and intravitreal air installation after PPV. Ophthalmic examination included standardized visual acuity testing and fluorescein angiography.

An unusual case of central serous chorioretinopathy in a patient with acute retinal necrosis.

Purpose: In acute retinal necrosis, which is caused by herpes virus, urgent treatment is essential.

Design And Methods: Here we present a 47 years old male patient, who developed an acute retinal necrosis in his left eye. Therapy was initiated with systemic aciclovir and corticosteroids.

Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells.

Dendritic cells (DC) are key regulators of immune responses. Mature DC are traditionally considered to be immunogenic, although there is accumulating evidence that they can also be tolerogenic and induce Ag-specific regulatory T cells (Tregs). However, the mechanism of this Treg induction and the site of Treg action in vivo are yet to be defined.

Adalimumab in the therapy of uveitis in childhood.

Purpose: Chronic anterior uveitis in children often takes a serious course. Despite various immunosuppressive drugs some children do not respond sufficiently and there is a high risk of them becoming seriously disabled. Anti-TNF alpha therapy has been shown by our group and others to be mostly ineffective (Etanercept) or partly effective (Infliximab) with the risk of anaphylactic reactions.

Intracameral bevacizumab for iris rubeosis.

Purpose: To determine whether intracameral bevacizumab decreases vascular leakage from iris rubeosis in patients with neovascular glaucoma.

Design: Interventional case series.

Methods: The study included six eyes of three patients with secondary neovascular glaucoma due to proliferative diabetic retinopathy (n = 2) or ischemic central retinal vein occlusion (n = 1).

CD4+CD25+ T regulatory cells induced by LPS-activated bone marrow dendritic cells suppress experimental autoimmune uveoretinitis in vivo.

Background: Tolerance-inducing DC are considered to be less mature than immunogenic DC, but the conditions promoting a less mature DC phenotype are not clear. We have previously shown that lipopolysaccharide (LPS) can have differential effects on DC function depending on the timing of DC exposure to LPS. Here, we show that early LPS-activated bone marrow derived DC (early DC, eDC), when administered subcutaneously to mice in vivo, promote tolerance to EAU induced via immunisation with interphotoreceptor retinol binding protein (IRBP) peptide 161-180.