Publications by authors named "Sabine A Hartlieb"
Article Synopsis
- - The study investigates telomere maintenance methods, specifically telomerase activation and alternative lengthening of telomeres (ALT), in primary and relapsed neuroblastomas, finding that ALT is linked to worse outcomes in patients.
- - Researchers analyzed 760 neuroblastoma cases and discovered that ALT-positive tumors have unique molecular characteristics, including lower ATRX/DAXX complex levels, mainly due to ATRX mutations or decreased protein expression.
- - Despite slower growth rates and a prolonged disease course, children with ALT-positive neuroblastomas experience poor prognoses, indicating a critical need for targeted clinical approaches.
Background: The number of patients age >65 years with malignant gliomas is increasing. Prognosis of these patients is worse compared with younger patients. To determine biological differences among malignant gliomas of different age groups and help to explain the survival heterogeneity seen in the NOA-08 trial, the prevalence and impact of recently established biomarkers for outcome in younger patients were characterized in elderly patients.
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