Meaningful Psychedelic Experiences Predict Increased Moral Expansiveness.

There has been growing interest in understanding the psychological effects of psychedelic experiences, including their potential to catalyze significant shifts in moral cognition. This retrospective study examines how meaningful psychedelic experiences are related to changes in moral expansiveness and investigates the role of acute subjective effects as predictors of these changes. We found that meaningful psychedelic experiences were associated with self-reported increases in moral expansiveness.

Correction: Olteanu et al. Gene Polymorphisms in Romanian Patients with Inflammatory Bowel Diseases: Association with Disease Risk and Clinical Features. 2023, 1465.

The authors wish to correct the authorship of the original publication [...

Automated Von Willebrand Factor Multimer Image Analysis for Improved Diagnosis and Classification of Von Willebrand Disease.

Introduction: Von Willebrand factor (VWF) multimer analysis is essential for diagnosing and classifying von Willebrand disease (VWD) but requires expert interpretation and is subject to inter-rater variability. We developed an automated image analysis pipeline using deep learning to improve the reproducibility and efficiency of VWF multimer pattern classification.

Methods: We trained a YOLOv8 deep learning model on 514 gel images (6168 labeled instances) to classify VWF multimer patterns into 12 classes.

Correction: Olteanu et al. Paradoxical Psoriasis Induced by Ustekinumab: A Comprehensive Review and Case Report. 2024, , 106.

In the original publication [...

Balancing the Load: How Optimal Forces Shape the Longevity and Stability of Orthodontic Mini-Implants.

: This study aims to investigate the mechanical behavior of titanium (Ti6Al4V) mini-implants (MIs) under varying orthodontic forces using finite element analysis (FEA) and to evaluate their performance and durability under realistic clinical conditions. Optimal orthodontic forces significantly influence the structural integrity and functional longevity of MIs while minimizing adverse effects on surrounding bone tissues. : A commercially available MI (diameter: 2.

Clonal plasma cell proportion in the synthetic phase identifies a unique high-risk cohort in multiple myeloma.

Risk stratification models based on cytogenetics and disease burden help identify high-risk patients with newly diagnosed multiple myeloma (NDMM). However, some high-risk patients remain undetected. This study evaluated the prognostic utility of the proportion of clonal plasma cells in the S-phase of the cell cycle for NDMM.

Comparative performance of PD-L1 scoring by pathologists and AI algorithms.

Aim: This study evaluates the comparative effectiveness of pathologists versus artificial intelligence (AI) algorithms in scoring PD-L1 expression in non-small cell lung carcinoma (NSCLC). Immune-checkpoint inhibitors have revolutionized NSCLC treatment, with PD-L1 expression, measured as the tumour proportion score (TPS), serving as a critical predictive biomarker for therapeutic response.

Methods And Results: In our analysis, 51 SP263-stained NSCLC cases were scored by six pathologists using light microscopy and whole-slide images (WSI), alongside evaluations by two commercially available software tools: uPath software (Roche) and the PD-L1 Lung Cancer TME application (Visiopharm).

A Unique Case of Extramedullary Relapse in Acute Lymphoblastic Leukemia: Testicular to Ocular, Cardiac, and Colonic Involvement and the Role of Sperm Phenotyping in Diagnosis-Case Report and Literature Review.

Acute lymphoblastic leukemia (ALL) is a malignant condition of lymphoid progenitor cells that primarily affects the pediatric population, but also adults. The 5-year survival rate is 90% in children and approximately 40% in adults, with survival increasing through the use of peripheral stem cell allotransplantation (SCT). The relapse rate after stem cell transplantation (SCT) in adult acute lymphoblastic leukemia (ALL) patients ranges from 35% to 45%, making relapse a major cause of death in this population.

Oral Breathing Effects on Malocclusions and Mandibular Posture: Complex Consequences on Dentofacial Development in Pediatric Orthodontics.

: Oral breathing is a common condition, particularly in children, and it is associated with significant changes in craniofacial development, dentomaxillary anomalies, and overall health. Despite extensive research, the role of oral breathing in the development of malocclusion remains controversial, with debates on whether it is a causative factor or a secondary adaptation to existing craniofacial issues. : This narrative review synthesizes studies published in the last 15 years, focusing on the impact of oral breathing on dentofacial development and mandibular posture.

Five Numerical Methods to Assess the Ischemic Risks in Dental Pulp and Neuro-Vascular Bundle Under Orthodontic Movements in Intact Periodontium In Vitro.

: Dental pulp and its neuro-vascular bundle (NVB) are among the least studied dental tissues. This study identified the best method for evaluating ischemic risks in the dental pulp and NVB of healthy lower premolars under orthodontic forces and in intact periodontium. : Nine 3D models of the second lower premolar were reconstructed based on the CBCT scans from nine patients.

The economic burden of atopic dermatitis in Romania: a broad perspective.

Introduction: Atopic dermatitis (AD), a common dermatological condition, is often associated with significant economic and social burdens. Despite extensive studies globally, there is a gap in understanding the impact of this condition in Romania. This study evaluated the economic burden of AD in Romania, considering both direct and indirect costs.

Exploring the use, perceptions, and challenges of mini-implants in orthodontic practice: a survey study.

Unlabelled: The present study aims to explore and evaluate current practices among orthodontic specialists regarding the use of mini-implants, focusing on factors influencing usage decisions, experience in placement, perceptions of outcomes, and future perspectives of these devices in orthodontic practice. It seeks to explore the association between specialists' experience levels and their perceptions of mini implants, as well as the challenges encountered in their use. It is hypothesized that orthodontic specialists' perceptions and practices regarding the usage of mini implants are influenced by various factors, including their experience, training engagement, treatment outcomes, and preferences.

Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources.

Polyunsaturated fatty acids (PUFAs) are vital dietary elements that play a significant role in human nutrition. They are highly regarded for their positive contributions to overall health and well-being. Beyond the fact that they provide a substantial supply of energy to the body (a role that saturated fats can also perform), these unsaturated fatty acids and, especially, the essential ones are involved in cell membrane structure, blood pressure regulation, and coagulation; participate in the proper functioning of the immune system and assimilation of fat-soluble vitamins; influence the synthesis of pro- and anti-inflammatory substances; and protect the cardiovascular system.

The Amount of Orthodontic Force Reaching the Dental Pulp and Neuro-Vascular Bundle During Orthodontic Movements in the Intact Periodontium.

: Most orthodontic forces are absorbed-dissipated before reaching the dental pulp and its neuro-vascular bundle (NVB); however, no data are available about their amounts. The objective of this study was to assess the amount of orthodontic force that reaches the dental pulp and its NVB during orthodontic movements in a healthy periodontium. : This study involved the second lower premolars of nine patients and 180 numerical simulations.

Retrospective Study on Orthodontic Gingival Recession Correction Using Clear Aligners.

: Our study aims to evaluate the effectiveness of ClearCorrect clear aligners (The Straumann Group) in improving gingival recession, which developed following prior fixed orthodontic treatment. The specific objectives were to assess changes in recession severity in patients with orthodontic gingival recessions following aligner therapy and to determine whether the initial severity of recession influenced improvement rates across three categories-mild (RT1), moderate (RT2), and severe (RT3)-as defined by the Cairo classification. Fifty-six patients with gingival recession from previous orthodontic treatment received aligner therapy for seven to twelve months, focusing on 146 recession sites, primarily in the lower anterior region.

Periodontal Breakdown, Orthodontic Movements and Pulpal Ischemia Correlations-A Comparison Between Five Study Methods.

: This study assessed the biomechanical behavior of dental pulp and the neuro-vascular bundle/NVB as well as the ischemic risks during orthodontic movements in a gradual horizontal periodontal breakdown, using five methods and aiming to identify the most accurate one. : Seventy-two models of second lower premolar (from nine patients) were subjected to 3 N of intrusion, extrusion, rotation, tipping, and translation. Five numerical methods, Tresca, Von Mises/VM, Maximum and Minimum Principal, and hydrostatic pressure were used in a total of 1800 numerical simulations.

Novel Immunohistochemical Profiling of Small-Cell Lung Cancer: Correlations Between Tumor Subtypes and Immune Microenvironment.

Background/objectives: Small-cell lung cancer (SCLC) is a highly aggressive malignancy with an emerging molecular classification based on the expression of the transcription factors ASCL1, NEUROD1, and POU2F3. This study aimed to explore the relationship between these novel subtypes and the tumor immune microenvironment (TIME), particularly CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs).

Methods: In 51 cases of patients with SCLC, immunohistochemical (IHC) stains for ASCL1, NEUROD1, POU2F3, CD56, Ki67, CD8, and CD4 were performed.

F-IVM: analytics over relational databases under updates.

This article describes F-IVM, a unified approach for maintaining analytics over changing relational data. We exemplify its versatility in four disciplines: processing queries with group-by aggregates and joins; learning linear regression models using the covariance matrix of the input features; building Chow-Liu trees using pairwise mutual information of the input features; and matrix chain multiplication. F-IVM has three main ingredients: higher-order incremental view maintenance; factorized computation; and ring abstraction.

Methodological review to develop a list of bias items for adaptive clinical trials: Protocol and rationale.

Background: Randomized-clinical trials (RCTs) are the gold-standard for comparing health care interventions, but can be limited by early termination, feasibility issues, and prolonged time to trial reporting. Adaptive clinical trials (ACTs), which are defined by pre-planned modifications and analyses that occur after starting patient recruitment, are gaining popularity as they can streamline trial design and time to reporting. As adaptive methodologies continue to be adopted by researchers, it will be critical to develop a risk of bias tool that evaluates the unique methodological features of ACTs so that their quality can be improved and standardized for the future.

Ischemic Risks Induced by Larger Orthodontic Forces on Dental Pulp and Neuro-Vascular Bundle in Reduced Periodontium.

There are few data about the ischemic risks induced by the large orthodontic forces during periodontal breakdown in dental pulp and neuro-vascular bundle (NVB) and none on the individual tissular stress distribution, despite their great importance for orthodontic treatment planning. Our aim was to assess, by a numerical analysis, the biomechanical behavior of dental pulp and the NVB during a simulated horizontal periodontal breakdown (1-8 mm), under 2-4 N of applied orthodontic forces and five movements (rotation, translation, tipping, intrusion, and extrusion). Additionally, the ischemic and degenerative-resorptive risks were assessed.

The Impact of Inflammatory Markers and Obesity in Chronic Venous Disease.

Chronic venous disease (CVD) represents a significant health challenge, particularly in obese individuals. This study focuses on the interplay between inflammation, obesity, and CVD, by analyzing the role of inflammatory markers in the disease progression. Clinical and paraclinical data of 619 patients hospitalized and treated in the Phlebology Department (1stSurgical Department, "Pius Brînzeu" Emergency County Hospital Timișoara, Romania) between 2018 and 2024 were analyzed.

Managing Crohn's Disease Postoperative Recurrence Beyond Prophylaxis: A Comprehensive Review with Meta-Analysis.

Background And Aims: Postoperative recurrence in Crohn's disease remains a significant clinical challenge, with high recurrence rates despite advancements in medical therapy. This study aims to evaluate the efficacy of various treatments for managing postoperative recurrence following ileocolonic resection in Crohn's disease.

Methods: A comprehensive search of PubMed, Cochrane, and Scopus databases was performed to identify studies reporting on the therapeutic management of postoperative recurrence in Crohn's disease.

The Effect of Larger Orthodontic Forces and Movement Types over a Dental Pulp and Neuro-Vascular Bundle of Lower Premolars in Intact Periodontium-A Numerical Analysis.

Background/objectives: This numerical analysis of stress distribution in the dental pulp and neuro-vascular bundle (NVB) of lower premolars assessed the ischemic and degenerative-resorptive risks generated by 2 and 4 N during orthodontic movements (rotation, translation, tipping, intrusion and extrusion) in intact periodontium.

Methods: The numerical analysis was performed on nine intact periodontium 3D models of the second lower premolar of nine patients totaling 90 simulations.

Results: In intact periodontium, both forces displayed a similar stress distribution for all five orthodontic movements but different amounts of stress (a doubling for 4 N when compared with 2 N), with the highest values displayed in NVB.