Impairment of brain vessels may contribute to mortality in patients with Parkinson's disease.

Background: The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied.

Methods: Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived.

Results: US/MRI data displayed a more-severe vascular impairment in deceased patients.

Iowa Gambling Task in patients with early-onset Parkinson's disease: strategy analysis.

The aim of our study was to analyse decision making in early-onset Parkinson's disease (PD) patients performing the Iowa Gambling Task (IGT). We compared 19 patients with early-onset PD (≤ 45 years) on dopaminergic medication (no evidence of depression, dementia, executive dysfunction according to the Tower of London test and the Stroop test, or pathological gambling) with 20 age-matched controls. A computer version of the IGT was employed.