Publications by authors named "Sabina Palma"

Rhomboid pseudoproteases are catalytically inactive members of the rhomboid superfamily that modulate the traffic, turnover and activity of their target proteins. Rhomboid domain containing 2 () is a rhomboid family member overexpressed during mammary gland development and advanced stages of breast cancer. Interactome profiling studies have identified RHBDD2 as a novel binding partner of WW domain‑containing oxidoreductase (WWOX) protein.

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Article Synopsis
  • RHBDD2 is a pseudoprotease associated with advanced breast cancer stages, with two distinct transcriptional variants leading to different protein isoforms.
  • This study found that RHBDD2 variant 2 is overexpressed in breast tumors compared to normal tissues and is linked to poor prognosis factors.
  • Additionally, under nutrient-deprived conditions, breast cancer cells switch from variant 1 to variant 2 as an adaptation to stress, indicating a possible new role for RHBDD2 in protein trafficking related to tumor progression.
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During the past years, molecular studies through high-throughput technologies have led to the confirmation of critical alterations in colorectal cancer (CRC) and the discovery of some new ones, including mutations, DNA methylations, and structural chromosomal changes. These genomic alterations might act in concert to dysregulate specific signaling pathways that normally exert their functions on critical cell phenotypes, including the regulation of cellular metabolism, proliferation, differentiation, and survival. Targeted therapy against key components of altered signaling pathways has allowed an improvement in CRC treatment.

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