Publications by authors named "Saber Ismail"
Article Synopsis
- The study aimed to compare two methods—chromocolonoscopy and the Colon Cancer-Specific Antigen-2 (CCSA2) test—for early detection of colorectal cancer (CRC) among Egyptian patients.
- It involved 55 participants divided into three groups: those with precancerous lesions, those diagnosed with CRC, and a control group, with various tests conducted, including stool occult blood measurement and serum CCSA2 levels.
- Results showed higher CCSA2 levels in CRC patients, with specific cutoff values revealing varying sensitivity and specificity, indicating that both CCSA2 tests and chromoendoscopy are effective for detecting CRC and related conditions.
Cytokeratin-18 in Diagnosis of HCC in Patients with Liver Cirrhosis.
Asian Pac J Cancer Prev
April 2017
Background: Hepatocellular carcinoma (HCC) is a common malignancy that occurs secondary to viral hepatitis B and C cirrhosis under the influence of environmental factors. In early stages, clinical diagnosis is often difficult and distinguishing HCC from cirrhosis and other hepatic masses by conventional tests is frequently not feasible. Physicians usually depend on measuring serum alpha-fetoprotein (AFP), but this marker has low sensitivity and specificity.
View Article and Find Full Text PDFBackground: Early diagnosis of hepatocellular carcinoma (HCC) is the most important step in successful treatment. However, it is usually rare due to the lack of a highly sensitive specific biomarker so that the HCC is usually fatal within few months after diagnosis. The aim of this work was to study the role of plasma nuclear factor kappa B (NF-?B) and serum peroxiredoxin 3 (PRDX3) as diagnostic biomarkers for early detection of HCC in a high-risk population.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma is a complex and heterogeneous tumor with poor prognosis due to frequent intrahepatic spread and extrahepatic metastasis. The molecular mechanisms underlying HCC pathogenesis still remain obscure.
Objectives: We aimed to investigate the abundance and the DNA binding activity of nuclear factor kappa B/p65 subunit in peripheral blood mononuclear cells from patients with HCC and to assess its prognostic significance and association with hypoxia inducible factor one alpha (HIF-1α) in blood.
Aim: To investigate the role of p53 antibodies (p53Abs), metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).
Methods: The study included 30 UC patients, 15 without dysplasia (group II) and 15 with dysplasia (group III), in addition to 15 healthy volunteers (group I, control subjects). The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs, while advanced oxidation protein products (AOPPs), and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.