The Role of Digitalization in the Target Scenario of Russian Economic Development.

The article considers the contribution of the ICT sector to the medium- and long-term development of the Russian economy. The target scenario of Russian economic development and the conditions necessary for its implementation are analyzed. The necessity of completing the ICT Ecosystem to full cycle is substantiated.

Celiac disease associated with ulcerative colitis.

The article provides clinical observation of a patient who was diagnosed with celiac disease when he was 52 years (Marsh stage IIIB). Following gluten-free diet (GFD) clinical remission and restoration of small intestinal mucosa (SIM) structure occurred, however in 6 years ulcerative colitis developed and an impairment of SIM morphological structure was identified (Marsh stage IIIA). Ulcerative colitis and celiac disease remission is supported by GFD, anti-cytokine therapy (adalimumab) in combination with mesalazine.

[All-Russian Consensus on Diagnosis and Treatment of Celiac Disease in Children and Adults].

The paper presents the All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults, which has been elaborated by leading experts, such as gastroenterologists and pediatricians of Russia on the basis of the existing Russian and international guidelines. The consensus approved at the 42nd Annual Scientific Session of the Central Research Institute of Gastroenterology on Principles of Evidence-Based Medicine into Clinical Practice (March 2-3, 2016). The consensus is intended for practitioners engaged in the management and treatment of patients with celiac disease.

[Whipple's disease: A clinical case report].

The paper describes a 56-year-old female patient who in December 2015 lost her appetite and 20 kg of weight, had diarrhea, rapidly increasing weakness, dizziness, joint pains, fever, swelling of the feet, and convulsions. Blood tests revealed anemia, elevated erythrocyte sedimentation rate, and hypoproteinemia. Computed tomography showed enlarged mesenteric and retroperitoneal lymph nodes.

[Impact of bariatric surgery on the absorption of nutrients in patients with obesity].

The review considers disturbed metabolism of vitamins, minerals, and protein in patients following bariatric surgery. The positive effect of the surgery is proven; however, postresection syndromes that may further occur determine not only a patient follow-up, but also timely therapeutic interventions to prevent hypovitaminoses, anemia, and mineral metabolic disturbances. There are conflicting data on the incidence of these abnormalities.

[Gluten-sensitive celiac disease associated with recurrent aphthous stomatitis and schizophrenia].

The paper describes a clinical case of celiac disease with grade 3 malabsorption, which is associated with recurrent aphthous stomatitis and schizophrenia. On readmission after 8 months of strict adherence to his gluten-free diet, the patient was observed to be in clinical remission and to have normalized laboratory indices and immunological tests. The signs of recurrent stomatitis disappeared.

[Specific features of rehabilitation in patients with gluten-sensitivity celiac disease].

Aim: To elaborate recommendations for rehabilitation of patients with gluten-sensitivity celiac disease (GCD) on the basis of a long-term follow-up.

Subjects And Methods: Eighty-seven patients with GCD were followed up for as long as 31 years. Of those, 72.

[Intolerance of gluten--a new disease or undiagnosed celiac disease].

The prevalence of celiac disease is about 1% in the population and is growing due to the wide use of immunological methods of diagnosis. In recent years, in-depth research of the celiac disease has led not only to an increase in the number of patients with celiac disease, but also to the emergence of a broad spectrum of diseases associated with the ingestion of gluten. In this regard, a new pathology, known as "gluten intolerance or gluten sensitivity", attracted special attention of researchers.

[Nutrition support of patients with celiac disease and deficiency of carbohydrases of the small intestinal mucosa].

The treatment policy of nutritive support for patients with different types of celiac disease is still actual issue. The difficulty of treatment policy implementation associated with villus atrophy, that brings on not only small intestine malabsorption function, but secretory process disorder (particularly, some of intestinal ferments production, including carbohydrases. The work objective is different types of celiac disease (typical, latent, torpid) nutritive correction improvement based on study of small intestine mucous membrane morphofunctional features at different stages of its atrophy, its carbohydrase activity that identifies clinic manifestation features, including nutritional disorders.

[Clinical aspects of intestinal dysbacteriosis].

The article presents data of domestic and foreign literature on intestinal dysbacteriosis. It is evident that intestinal dysbiosis always secondary and its correction should take into account the reasons that caused the violation of the microbial composition of the intestinal flora and the clinical manifestations of this syndrome. The characteristic of the normal intestinal microflora and its significance for the human body.

[Asymptomatic celiac disease in patient with chronic acalculous cholecystitis].

We described a patient 40 years old, admitted to the clinic with periodic attacks of pain in the right upper quadrant. With ultrasound it was confirmed chronic acalculous cholecystitis, and at endoscopy and multiple biopsies revealed atrophy of the mucosa of the duodenum (DM), corresponding to celiac disease (stage III in the Marsh classification). Titer of antibodies to gliadin (AGA) and tissue transglutaminase (AtTG) were higher: 60 and 110 units/ml, respectively, at a rate of 10 units/ml.

[Importance of the immunogenetic factors in the development of glutensensitive celiac disease in adults of Moscow region].

The study examined the genetic predisposition to the development of glutensensitive celiac disease (CD). Were analyzed samples of peripheral blood of 17 adult patients diagnosed with CD, as well as samples of umbilical cord blood of 1700 newborns of healthy children. HLA-typing was performed using two basic methods of molecular typing--SSO and SSP.

[Reproductive disorders in women with celiac disease. Effect of the etiotropic therapy].

Unlabelled: Violation of reproductive function in patients with celiac disease can manifest as delayed puberty, infertility, amenorrhea, premature menopause, spontaneous abortion, low birth weight. The aim of the study was to establish the frequency and nature of reproductive function violation in patients with CD in the Russian Federation.

Materials And Methods: The study included 132 women (average age 38,5 +/- 1,17 years) with CD observed in CSRIG in the period from 2000 to 2010.

[Treatment and prevention of gluten-sensitive celiac disease].

In this article presented results of examination and treatment of 207 patients with glutensensitive celiac disease. And also you can find comprehensive method for the treatment of patients with varying severity of disease. The fundamental method of therapy glutensensitive celiac disease is strict lifelong adherence to a gluten-free diet (GFD), which eliminated protein cereal--gluten contained in wheat, rye and barley.

[Functional condition of the stomach, pancreas, liver and gallbladder in celiac disease].

Aim: To study condition of the stomach, gall-bladder, pancreas, liver in celiac disease (CD) and contribution of their dysfunction to clinical presentation of CD symptoms.

Material And Methods: A total of 215 CD patients entered the study (191 females and 24 males) aged under 20 years (n=100), 20 to 50 (n=74) and over 50 years (n=41). The control group consisted of 25 healthy volunteers.

[The problems of organization of diet nutrition at the patients with gluten-sensitive enteropathy (celiac disease) in Russia].

Gluten-sensitive enteropathy (Celiac Disease)--is an autoimmune inflammatory disease, with hyper Regenerative atrophy of the mucous membrane of the small intestine, that is precipitated by the ingestion of gluten, a component of wheat rye, barley, protein. Exclusion of dietary gluten results in healing of the mucosa of the small intestine. The main method of treatment and prevention of complications of celiac disease is strict lifelong adherence to gluten-free diet (AGD), which reduces the quality of life of patients.

[Celiac disease in the elderly patients].

The incidence of celiac disease in the elderly patients in recent years is increasing and is 7.2% of all examinees. More than half of patients with onset of the disease is characterized by severe malabsorption syndrome III degree and is diagnosed in a short time from the first signs of illness.

[Autoimmune reactions in diseases of the digestive system organs].

Aim: To examine content, diagnostic and prognostic role of autologous antibodies in gastrointestinal diseases (GID).

Material And Methods: Enzyme immunoassay was used to measure content of autologous antibodies to N+/K+ ATPase (Aab) of gastric parietal cells, mitochondria, microsomes, tissue transglutaminase in blood serum of 196 patients with gastric, gallbladder, small and large intestinal diseases. Aab relations with heterologous antibodies were studied with kits provided by Bektor-Best (Novosibirsk), DRG-Diagnostics, Orgentec (Germany) and others.

[Specific immune response in diagnosis of celiac disease with chronic diarrhea].

High concentration of Ab Gl, Ab tTG, Ab Em and Ab Rt and increased amount of immunocompetent cells in the SIM in coeliac disease is an index of the developing specific immune response to gliadin and tissue antigens. High specificity and sensitivity of Ab tTG and Ab Em were determined in celiac disease.

[Correction of protein metabolism violations in patients with malabsorption syndrome].

It is established that a heightened nitrogen balance is defined by a dysabsorbtion syndrom. Proved that the optimal quota of protein at albuminous insufficiency is about 135 g/day. Parenteral introduction of aminoacidic mixes (Infesol) led to clinical improvement, normalization of an aminoacidic spectrum of blood.