Publications by authors named "Sabbu Satish"
Article Synopsis
- L. stem extract is utilized for various health benefits including acting as a purgative, febrifuge, and diuretic, as well as treating flu, fever, and bone diseases, with certain compounds showing osteogenic effects.
- This study aimed to develop a sensitive LC-MS/MS method for simultaneously detecting five specific biomarkers in rat plasma after administering 500 mg/kg of COEE.
- Findings revealed that the biomarkers were quickly absorbed, stable in simulated digestive environments, but metabolized in the liver, providing foundational knowledge for future pharmacokinetic research and clinical applications of COEE.
Article Synopsis
- - The study explores the effectiveness of a synthetic compound, 10C, modeled after a natural product called Aegeline, as a potential β3-AR agonist to tackle insulin resistance and hyperlipidemia.
- - Researchers utilized 3D pharmacophore modeling to screen 20 synthetic derivatives of Aegeline, with 10C being identified as the most active β3-AR agonist through various experimental validations, including tests on human stem cell-derived adipocytes.
- - Results showed that compound 10C significantly activated the β3-AR pathway, promoting processes like lipolysis and fatty acid oxidation, which hints at its potential role in improving metabolic health.
Excess adiposity is a hallmark of obesity, which is caused due to an imbalance between energy intake and energy consumed. Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, our group had reported natural product Aegeline (amino-alcohol) isolated from the plant Aegle marmelos as an anti-diabetic and anti-dyslipidemic compound.
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