[Immunosuppressive activity of halothane. A study using the lymphoblastic transformation test (LTT)].

Halothane in concentration of 1p. 100 or 2p. 100 blocked DNA synthesis in lymphocytes cultured with 0.

[A study of allergy to local anesthetics using the lymphoblast transformation test].

The lymphocyte transformation test (LTT) confirms the classical concept that Novocain is three times as potent as Xylocaine as a sensitizing agent. This sensitization to Novocaine is more common in patients with an allergic constitution and in those treated with several drugs. The LTT made it possible to identify the responsible drug, which was not always a local anesthetic, but sometimes Penicillin G and aspirin.

[Immunobiological means of identifying hypersensitivity to anesthetics and adjuvants].

The diagnosis of hypersensitivity to anesthetics and adjuvants is based chiefly on immunobiological tests which involve:-sensitized lymphocytes; -IgE or IgG antibodies; -sensitized target cells; -determination of chemical mediators. Comparison between these different methods is only possible for techniques involving the sensitized lymphocyte, such as the LTT and EA rosettes for examples, or T.D.