Publications by authors named "Sabal Al Hadidi"
Article Synopsis
- Charcot-Marie-Tooth disease (CMT) is a genetic condition that impacts the peripheral nervous system.
- A new induced pluripotent stem cell (iPSC) line, JUCTCi018-A, was developed from skin cells of a CMT2EE patient carrying a specific mutation in the MPV17 gene.
- This iPSC line exhibits normal characteristics and pluripotency, making it a useful tool for studying the mechanisms of CMT2EE.*
Article Synopsis
- Mesenchymal stem cells (MSCs) often face high mortality rates after transplantation, making hypoxia pre-conditioning a vital technique to enhance their survival and functionality.
- Induced pluripotent stem cell-derived MSCs (iMSCs) are emerging as a promising alternative, and this study investigated how short-term severe hypoxia (1% O for 24 hours) affects their growth, viability, and differentiation.
- The results showed that while hypoxia negatively impacted iMSCs' proliferation and viability, it might have long-term benefits for their growth and differentiation, indicating a need for further research on the effects of prolonged hypoxia recovery.
Objective: Gingival tissue regeneration is associated with several challenges. Tissue engineering regenerates the different components of the tissues, providing three major elements: living cells, appropriate scaffolds, and tissue-inducing substances. This study aimed to regenerate the gingival connective tissue in vitro, using human gingival fibroblasts cultured in three-dimensional fibrin gel scaffolds.
View Article and Find Full Text PDFCancer is a worldwide health problem and is the second leading cause of death after heart disease. Due to the high cost and severe side effects associated with chemotherapy treatments, natural products with anticancer therapeutic potential may play a promising role in anticancer therapy. The purpose of this study was to investigate the cytotoxic and apoptotic characteristics of the aqueous bulb extract on Caco-2 and COLO-205 colorectal cancer cells.
View Article and Find Full Text PDFCharcot-Marie-Tooth disease (CMT) is an inherited neurological disorder characterized by the progressive damage of the peripheral nerves. We generated a human induced pluripotent stem cell (iPSC) line JUCTCi019-A using dermal fibroblasts-derived from a 50-year-old CMT2A2 patient carrying a heterozygous missense substitution c.2119C > T (p.
View Article and Find Full Text PDFLimb-girdle muscular dystrophies (LGMDs) are a large group of heterogenous genetic diseases characterized by muscle weakness. In this study, an induced pluripotent stem cell (iPSC) line was generated from LGMD patient's skin dermal fibroblasts, carrying a homozygous mutation in the Sarcoglycan Beta (SGCB) gene; chr4:52890221, c. 859 delC, p.
View Article and Find Full Text PDFInduced pluripotent stem cells (iPSCs) were generated from skin fibroblasts collected from a 39-year-old multiple symmetric lipomatosis (MLS) female patient carrying a point mutation in MFN2 gene (c.2119C > T). The resulting iPSCs showed typical embryonic-like morphology, expressed pluripotency stem cell markers, retained the normal karyotype after reprogramming and showed the potential to differentiate into three germ layers.
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