Publications by authors named "Sabai Myo Aye"
Article Synopsis
- STAT4 plays a crucial role in T-helper cell differentiation and is linked to adipose tissue inflammation, which is significant in obesity.
- Researchers studied mice lacking STAT4 (STAT4(-/-)) and found they developed obesity from a high-fat diet, similar to regular mice, but showed better insulin sensitivity and glucose tolerance.
- The study revealed that these STAT4(-/-) mice had lower levels of inflammatory markers and CD8(+) cells in fat tissues, indicating that targeting STAT4 may be an effective strategy for reducing inflammation and improving insulin resistance related to obesity.
