Quercus infectoria galls mitigates colitis in mice through alleviating mucosal barrier impairment and suppressing inflammatory factors.

Ethnopharmacological Relevance: Xipayi Kuijie'an herbal enema preparation, a traditional Uyghur medicinal preparation derived from Quercus infectoria galls (QIG), has been clinically employed at Xinjiang Uyghur Medical Hospital for ulcerative colitis (UC) management. Despite its well-documented therapeutic efficacy, the precise mechanisms underlying its pharmacological actions remain poorly understood.

Aim Of Study: This study aimed to elucidate the therapeutic mechanisms of QIG against UC through an integrated approach combining network pharmacology analysis with experimental validation.