The influence of Nrf2 gene promoter methylation on gene expression and oxidative stress parameters in preeclampsia.

Background And Aims: Preeclampsia (PE) is a serious medical condition that usually causes high blood pressure and affects multiple organs. Considering the adverse effect of oxidative stress on the process of PE in pregnant women and regarding the role of the Nrf2 gene in placental oxidative pathways, this study was conducted to investigate the DNA methylation status of Nrf2 in PE and healthy pregnant women.

Materials And Methods: The present case-control study consisted of 70 PE and 70 healthy pregnant women.

Aberrant Methylation of the GENE, its Expression and Enzyme Activity in the Placenta of Patients with Preeclampsia.

Background: Oxidative stress is involved in the pathogenesis of preeclampsia (PE). Dysregulation of may be involved in the pathogenesis of PE. We examined and compared the methylation level of the promoter region (PMR) of the , gene expression, and enzyme activity of superoxide dismutase (SOD) in both placenta and maternal blood in PE women.

COVID-19 and renin angiotensin aldosterone system: Pathogenesis and therapy.

Aims: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the ACE2 component of the renin-angiotensin aldosterone system (RAAS) and infects the human cells. The aims of the present review were to look at the role and alteration of the RAAS components in SARS-CoV-2 infection, therapeutic approaches, and clinical trials in this field.

Methods: We surveyed the literature (PubMed, Web of Science, and Scopus) till August 18, 2021, and 59 published papers regarding the components of the RAAS and their role and alterations in SARS-CoV-2 infection along with various COVID-19 therapies based on the RASS components were included in the study.

Comment on "Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome".

No Abstract.

Nanolipodendrosome-loaded glatiramer acetate and myogenic differentiation 1 as augmentation therapeutic strategy approaches in muscular dystrophy.

Background: [Corrected] Muscular dystrophies consist of a number of juvenile and adult forms of complex disorders which generally cause weakness or efficiency defects affecting skeletal muscles or, in some kinds, other types of tissues in all parts of the body are vastly affected. In previous studies, it was observed that along with muscular dystrophy, immune inflammation was caused by inflammatory cells invasion - like T lymphocyte markers (CD8+/CD4+). Inflammatory processes play a major part in muscular fibrosis in muscular dystrophy patients.