Publications by authors named "Saba H"

In densely populated urban areas, air quality is one of the main concerns, affecting human health and the environment. In developing and emerging countries, an alternative method for reducing the effects of air pollution is to select vehicles with lower pollutant emissions, as a way of making these large centers more sustainable. Since the complete elimination of vehicle emissions is not possible in the short term.

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Background: While bidirectional endoscopy is recognized as the standard approach for investigating iron deficiency anemia (IDA) in men older than 45 and postmenopausal women, evidence supporting the application of this approach in younger men and premenopausal women is scarce in the absence of symptoms. Our primary aim is to identify the diagnostic yield of bidirectional endoscopy in men younger than 45 and premenopausal women, and describe the clinical characteristics of those with significant endoscopic and pathology-proven findings.

Methods: We performed a retrospective chart review including patients younger than age 45 with IDA who underwent esophagogastroduodenoscopy (EGD) and/or colonoscopy at the Brooklyn VA Hospital between 2009 and 2023.

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Article Synopsis
  • - The study investigates the prevalence of inherited cancer susceptibility variants in patients with pancreatic cancer and nonpancreatic periampullary cancers, emphasizing that both groups show similar rates of these variants.
  • - A total of 608 patients were analyzed, revealing that 7.7% carried significant germline variants, with 89% linked to major cancer susceptibility genes and a notable majority having a family cancer history.
  • - The findings support the recommendation for germline susceptibility testing in all patients with periampullary cancers, not just those with pancreatic cancer.
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Drug-induced liver injury (DILI) presents a significant challenge in clinical practice, particularly with the rising popularity of herbal and dietary supplements (HDS) in the United States. Tongkat Ali (Eurycoma longifolia Jack), a Southeast Asian herb, has garnered attention for its purported health benefits, including enhancing testosterone levels. Here, we present a case of a 47-year-old male with acute liver injury following Tongkat Ali use, the first reported case of its kind in the literature.

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Introduction/objectives: To assess the utility of the computerized cognitive function assessment tool, CogEvo, as a screening tool for mild cognitive impairment in primary care, we explored the relationship between CogEvo performance, age, and the severity of cognitive dysfunction evaluated by the Mini-Mental State Examination (MMSE).

Methods: The observational cross-sectional study included 209 individuals' data (mean age 79.4 ± 8.

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  • The study explores how levels of the carbohydrate antigen CA19-9 and a related glycan, DUPAN-2, can aid in diagnosing pancreatic cancer, particularly highlighting differences based on genetic variants in fucosyltransferase (FUT) enzymes.
  • It involved analyzing genetic data from 938 individuals to determine how these variants affect serum levels of DUPAN-2 and CA19-9, with findings suggesting improved diagnostic sensitivity for early-stage pancreatic cancer.
  • The conclusion emphasizes the potential of combining genetic testing with tumor markers to enhance diagnostic accuracy for pancreatic cancer, showing promising results when using a combination of FUT, CA19-9, and DUPAN-2 tests.
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  • Cancer antigen 19-9 (CA19-9) is a key marker used to monitor pancreatic cancer but varies based on genetic factors from fucosyltransferase (FUT) variants, influencing its reference ranges in patients.
  • The study evaluated preoperative CA19-9 levels in 449 pancreatic cancer patients, analyzing how these levels and FUT variants correlate with survival outcomes.
  • Results indicated that higher CA19-9 levels were linked to worse outcomes in patients with higher FUT groups, while a variant-based CA19-9 test enhanced prediction of treatment response and recurrence after surgery.*
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  • The study investigates how regular use of proton pump inhibitors (PPIs) impacts the microbiomes of pancreatic and duodenal tissues, especially in relation to pancreatic cancer risk.
  • It analyzes microbiome profiles from 103 patients, revealing that PPI users have a significantly altered duodenal microbiome, with notable enrichment of Firmicutes and Streptococcus species.
  • The research highlights differences in microbiome diversity between the pancreas head and body/tail, finding that PPI use is linked to changes in both duodenal and pancreatic tissue microbiome profiles, although more pronounced effects were noted in the duodenum.
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Purpose: CA19-9 synthesis is influenced by common variants in the fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect FUT variants, and evaluated its diagnostic performance for pancreatic ductal adenocarcinoma (PDAC).

Experimental Design: A representative set of controls from the Cancer of the Pancreas Screening study was identified for each FUT functional group.

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Arbovirus can cause diseases with a broad spectrum from mild to severe and long-lasting symptoms, affecting humans worldwide and therefore considered a public health problem with global and diverse socio-economic impacts. Understanding how they spread within and across different regions is necessary to devise strategies to control and prevent new outbreaks. Complex network approaches have widespread use to get important insights on several phenomena, as the spread of these viruses within a given region.

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Aim: The aim of this study was to determine the validity and reliability of cognitive function evaluation battery, CogEvo, a recently developed computerized cognitive function evaluation battery, as a screening tool for decreased cognitive function.

Methods: The study sample comprised 123 (age: 57-97 years) community-dwelling elderly people. They were required to perform five CogEvo tasks and complete two questions-based neuropsychological tests, including the Mini-Mental State Examination, so that the correlations could be analyzed.

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Background: Dengue fever is a tropical disease and a major public health concern, and almost half of the world's population lives in areas at risk of contracting this disease. Climate change is identified by WHO and other international health authorities as one of the primary factors that contribute to the rapid spread of dengue fever.

Methods: We evaluated the effect of sanitation on the cross-correlation between rainfall and the first symptoms of dengue in the city of Mato Grosso do Sul, which is in a state in the Midwest region of Brazil, and employed the time-lagged detrended cross-correlation analysis (DCCAC) method.

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Familial Pancreatic Cancer.

Gastroenterol Clin North Am

September 2022

Individuals at increased risk of developing pancreatic cancer, including those with a significant family history of the disease and those with pancreatic cancer susceptibility gene variants, can benefit from pancreas surveillance. Most pancreatic cancers diagnosed during surveillance are early-stage and such patients can achieve long-term survival. Determining who should undergo pancreas surveillance is still a work-in-progress, but the main tools clinicians use to estimate an individual's risk of pancreatic cancer are patient's age, the extent of their family history of pancreatic cancer, and whether or not they have a pancreatic cancer susceptibility gene mutation.

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Several vaccines against COVID-19 are now available, based on different techniques and made by different laboratories spread around the world. With the roll out of the vaccination process in an advanced stage in many countries, the reduced risk of hospitalization due to the Omicron variant relative to the Delta variant infection, despite the higher transmission risk of Omicron, may lead to a misinterpretation of the results, as infection by Omicron is associated with a significant reduction in severe outcomes and shorter hospitalization time than the Delta variant. We compared the in-hospital mortality due to the Omicron (Jan-Mar 2022) with Gamma (Jan 2021) and Delta (Oct-Dec 2021) variants of patients in the Brazilian public health system.

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The COVID-19 pandemic, caused by the highly transmissible SARS-CoV-2 virus, has overloaded health systems in many contexts Conant and Wolfe (2008). Brazil has experienced more than 345,000 deaths, as of April/2021 Conant and Wolfe (2008), with dire consequences for the country's public and private health systems. This paper aims to estimate the synchronization graph between the cities' contagion waves from public COVID-19 data records.

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Background: Post-dural puncture headache (PDPH) is a severe positional headache that appears usually within 72 hours after inadvertent dural puncture, secondary to cerebrospinal fluid leakage. It is treated first by conservative treatment (including bed rest, hydration, caffeine and simple analgesia) and then by invasive procedures such as blood patch. This study aims to evaluate factors associated with PDPH among a sample of Lebanese patients and assess the rate of success of different treatment modalities administered in a specific sequence: conservative treatment first, then ultrasound-guided bilateral greater occipital nerve block (GONB) if failure of conservative treatment and finally epidural blood patch (EBP) if failure of GONB.

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To effectively combat the COVID-19 pandemic, countries with limited resources could only allocate intensive and non-intensive care units to a low number of regions. In this work, we evaluated the actual displacement of infected patients in search of care, aiming to understand how the networks of planned and actual hospitalizations take place. To assess the flow of hospitalizations outside the place of residence, we used the concepts of complex networks.

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On the >1 µm scale the morphology of semicrystalline plastics like polyethylene or Nylon features spherulites, "shish-kebabs", cylinddrites and other crystalline aggregates which strongly affect mechanical and other material properties. Current imaging techniques give only a 2D picture of these objects. Here we show how they can be visualized in 3D using fluorescent labels and confocal microscopy.

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We investigated the relation between the spread, time scale, and spatial arrangement of dengue in Bahia, a Brazilian dry climate region, for the period 2000 to 2009. The degree of cross-correlation is calculated for 15 economic regions. We propose a multiscale statistical analysis to datasets of dengue cases in order to verify the effect of infection dispersal on the economic regions from the metropolitan region of Salvador.

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Groundwater is a vital component of water supply for residential, industrial, and agricultural purposes. However, many groundwater basins are being used unsustainably and groundwater contamination is a growing water quality problem. Although anthropogenic activities and natural processes have been increasing the contamination in this valuable water resource, several remediation techniques have been developed in the last few decades to reduce these contamination levels.

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In this paper, we provide a retrospective cohort study with patients that have been hospitalized for general or intensive care unit admission due to COVID-19, between March 3 and July 29, 2020, in the state of Bahia, Brazil. We aim to correlate those patients' demographics, symptoms and comorbidities, with the risk of mortality from COVID-19, length of hospital stay, and time from diagnosis to definitive outcome. On the basis of a dataset provided by the Health Secretary of the State of Bahia, we selected 3,896 hospitalized patients from a total of 154,868 COVID-19 patients that included non-hospitalized patients and patients with invalid registration in the dataset.

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Article Synopsis
  • The Covid-19 pandemic has caused widespread suffering and economic disruption globally, making it crucial for authorities to understand the disease's spread and characteristics for effective interventions.
  • A hybrid model incorporating local SIR models and population flow networks provides a more accurate representation of contagion dynamics compared to traditional models that assume uniform contact rates among municipalities.
  • By highlighting the importance of local variations and inter-municipality transport, the study suggests that early restrictions on movement can significantly help in controlling the spread of the virus.
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Strongyloides is a unique nematode in its ability to cause a secondary hyperinfection and disseminated disease several years following initial contact. The prevalence of Strongyloides infection has been rising; it is currently considered a global disease, which presents with a broad spectrum of clinical signs and symptoms among patients. This case report focuses on a 67-year-old Caribbean female presenting with severe weight loss, vomiting, early satiety, and mild anemia who was subsequently diagnosed with strongyloidiasis on the basis of a duodenal biopsy pathology report obtained via esophagogastroduodenoscopy (EGD).

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