Publications by authors named "Saba E"
Article Synopsis
- Mepolizumab is effective for eosinophil-associated disorders like eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), but traditional treatments often fall short and have side effects.
- The study aimed to analyze adverse reactions related to mepolizumab in CRSwNP patients by using data from the FDA Adverse Event Reporting System between Q1 2021 and Q1 2023.
- Results indicated that CRSwNP patients experienced significantly fewer adverse reactions compared to asthma patients, with common issues being pulmonary, generalized, neurologic, and hematologic, and concurrent asthma treatment raised the risk for serious reactions in CRSwNP cases.
Article Synopsis
- This study investigates otologic issues in patients with aspirin exacerbated respiratory disease (AERD) to see if more severe sinonasal inflammation leads to more ear-related problems.
- The research included 255 AERD patients, with over half experiencing otologic conditions like otitis media and vertigo, yet no significant link was found between sinonasal inflammation severity and otologic issues.
- The findings suggest that ear problems are prevalent in AERD patients, highlighting the need to consider these symptoms for better patient care, despite no clear correlation to sinonasal inflammation levels.
From forgotten cure to modern medicine: The resurgence of bacteriophage therapy.
J Glob Antimicrob Resist
December 2024
Objectives: The unregulated use of antibiotics has led to the rise of antibiotic-resistant bacterial strains. This study explores bacteriophage therapy as an alternative treatment, highlighting its history, significance, and advancements in Europe, the United States, and the Middle East.
Methods: A comprehensive literature review on bacteriophage therapy was conducted, focusing on its development, clinical trials, and patient treatment applications.
Article Synopsis
- Compromised heart function and high pulmonary vascular resistance are common in neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy, but limited data exist on heart health post-NICU discharge.
- An evaluation of 70 neonates showed those with initial abnormal aEEG profiles had significantly reduced right ventricular strain and contraction compared to those with normal aEEG, suggesting ongoing cardiac issues.
- The findings stress the importance of long-term cardiovascular monitoring in these infants to better understand their health outcomes beyond their initial treatment.
Detection and molecular characterization of avian polyomavirus in budgerigar and non-budgerigar psittacine species in bird markets of Pakistan.
Comp Immunol Microbiol Infect Dis
December 2024
Article Synopsis
- * A study investigated the presence of these viruses in feather and tissue samples, finding a 12% positivity rate for Avian Polyomavirus in Psittacine birds, with particular emphasis on budgerigars.
- * The research highlights the lack of data on Avian Polyomavirus in Pakistan and serves as a foundational step for future studies on diagnosis and vaccine development.
Objectives: To evaluate otologic adverse reactions (OARs), including hearing loss (OARs-HL) among patients taking teprotumumab, a new biologic approved for the treatment of active thyroid eye disease, using publicly available pharmacovigilance reporting data.
Study Design: Retrospective database review.
Methods: The Food and Drug Administration Adverse Events Reporting System (FAERS) was queried for cases involving teprotumumab from 2020Q1 to 2023Q1.
Article Synopsis
- The text addresses a correction to the scientific article identified by the DOI 10.1016/j.jgr.2019.05.003.!
- It indicates that there was an error in the original publication that needs to be amended.!
- The correction ensures that the information presented in the article is accurate and reliable for readers and researchers.!
Background: Platelet-leukocyte aggregates (PLAs) play important roles in cardiovascular disease and sepsis. Red ginseng extract (RGE) has been well-studied for its antiplatelet and anti-inflammatory activities. However, the potential inhibitory effects of RGE on PLA have not been investigated.
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- A study investigates how adenotonsillectomy (AT) affects healthcare utilization in children aged 3-12 diagnosed with obstructive sleep apnea (OSA), revealing a gap in previous research regarding OSA severity groups.
- The research used retrospective data from 577 children, analyzing their medical visits and prescription patterns before and after undergoing surgery, utilizing methods like difference-in-difference models to assess impact.
- Results indicate that the healthcare utilization patterns of children with OSA are poorly understood post-surgery, emphasizing the need for more in-depth analysis on the implications of surgical treatments.
Canine mesenchymal stromal cells (MSCs) possess the capacity to differentiate into a variety of cell types and secrete a wide range of bioactive molecules in the form of soluble and membrane-bound exosomes. Extracellular vesicles/exosomes are nano-sized vesicles that carry proteins, lipids, and nucleic acids and can modulate recipient cell response in various ways. The process of exosome formation is a physiological interaction between cells.
View Article and Find Full Text PDFObjective: In regenerative biology, the most commonly used cells are adipose tissue-derived mesenchymal stem cells (AD-MSCs). This is due to the abundance and easy accessibility of AD-MSCs.
Methods: In this study, canine AD-MSCs were harvested from different anatomical locations, i.
Antiplatelet and Antithrombotic Activities of via Pharmacological Inhibition of Integrin IIb3, MAPK, and PI3K/AKT Pathways and FeCl3-Induced Murine Thrombosis.
Evid Based Complement Alternat Med
February 2024
Article Synopsis
- Cardiovascular diseases (CVDs) are a leading cause of death worldwide, prompting research into potential treatments.
- Extracts from the plant Dumont de Courset were analyzed for their effects on platelets and blood clotting, showing promise for cardiovascular health due to the presence of short-chain fatty acids.
- The study found that the extract significantly inhibited platelet aggregation and clot formation while also improving blood flow and survival rates in test animals, suggesting its potential use as a natural alternative to synthetic cardiovascular drugs.
Article Synopsis
- - This study explores the link between an anaerobic bacterium associated with periodontal disease and the development of pancreatic ductal adenocarcinoma (PDAC) by analyzing its impact in a mouse model.
- - Researchers tracked how the bacteria moved from the mouth to the pancreas and observed that it accelerated the progression from pancreatic intraepithelial neoplasia (PanIN) to PDAC while affecting cell behavior in vitro.
- - The findings suggest that this bacterium plays a significant role in promoting pancreatic cancer, indicating a potential new avenue for understanding cancer development.
Microdebrider complications in sinus surgery: Analysis of the openFDA database.
World J Otorhinolaryngol Head Neck Surg
December 2023
Objective: Functional endoscopic sinus surgery is a commonly performed otolaryngologic procedure that often uses the microdebrider device for tissue removal. Given the ubiquitous nature of the instrument, we sought to better define the patterns of device failure using the postmarket surveillance openFDA database.
Methods: The openFDA database was queried for all microdebrider-related adverse events from January 1, 2000 to November 1, 2020.
Background: Nontuberculous mycobacterial cervicofacial lymphadenitis (NTMCL) is an uncommon condition detected in young immunocompetent children who typically present with a nontender neck mass. Various tests have been proposed to assist in the work-up of suspected NTMCL, with varying diagnostic utility. This systematic review investigates the sensitivity of the various diagnostic methods used in the work-up of pediatric NTMCL.
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- The study investigates the use of autologous platelet lysate (A-PL) as a replacement for fetal bovine serum (FBS) in culturing canine mesenchymal stem cells (cMSCs), addressing ethical and scientific issues associated with FBS.
- Results showed that varying combinations of A-PL and FBS did not negatively impact cMSC cell growth and viability, while enhancing their ability to differentiate into multiple cell types, particularly in the media with 10% A-PL.
- These findings suggest that A-PL is a viable alternative to FBS, potentially improving the development of cMSCs for regenerative medicine under good manufacturing practices.
Objective: Orofacial myofunctional therapy (OMT) is an alternative form of treatment of obstructive sleep apnea (OSA), that incorporates various exercises to optimize tongue placement and increase oropharyngeal tone. The objective of this systematic review and meta-analysis is to determine the efficacy of OMT in OSA patients.
Data Sources: PubMed/Medline, EMBASE, Cochrane, Web of Science.
Objectives: The objectives of this study are to (i) estimate the incidence of vestibular schwannoma (VS) among patients in an integrated healthcare system who present for evaluation of sudden sensorineural hearing loss (SSNHL) and (ii) evaluate the efficacy of empiric steroid therapy on audiologic recovery among SSNHL patients ultimately diagnosed with VS.
Methods: A retrospective chart review was performed on patients presenting with SSNHL in 2021 at a multicenter integrated healthcare system serving over 4 million members. Patient demographics, audiometric data, VS diagnosis, therapeutic steroid intervention, and data regarding treatment response were recorded.
Pediatric vagal nerve stimulator explantation: A comprehensive literature review and tertiary care experience.
Int J Pediatr Otorhinolaryngol
July 2023
Objective: Patients with medically-refractory epilepsy who undergo vagal nerve stimulator (VNS) implantation to reduce seizure burden sometimes require device removal. Complete explantation refers to the removal of both the generator and vagal nerve leads, and is uncommonly performed by otolaryngologists due to the perceived risk associated with lead removal. This comprehensive literature review and case series studies safety outcomes among pediatric patients undergoing complete VNS explantation.
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- The study examined how the growth of Pinus heldreichii, a pine species, responds to varying air temperatures across different elevations in the southern Italian Apennines.
- Researchers conducted fieldwork over three years, collecting wood cores from 214 trees to assess growth patterns and climatic influences using a combination of tree-ring analysis and genetic methods.
- The findings revealed a bell-shaped relationship between tree growth and air temperature, with increased growth at higher elevations linked to warmer temperatures, as well as a strong positive correlation between growth and April mean temperatures, indicating the trees' ability to acclimate to changing climatic conditions.
Objective: The interruption of vascular supply to the inner ear is one of several proposed etiologies of sudden sensorineural hearing loss (SSNHL). The increased presence of cardiovascular risk factors may predispose patients to SSNHL through this pathway. This systematic review and meta-analysis studies the presence of cardiovascular risk factors in patients diagnosed with SSNHL.
View Article and Find Full Text PDFEvaluating the impact of a cemetery on groundwater by multivariate analysis.
Environ Monit Assess
January 2023
Water analyses in conjunction with hydrological and geotechnical investigations were carried out to assess the potential for groundwater contamination from the decomposition of buried human bodies. Water samples were collected from 2007 to 2018 in three monitoring wells built within the cemetery area. Water quality was evaluated based on the determination of 25 analytical parameters (20 physical-chemical and 5 microbiological).
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- Ulcerative colitis (UC) is a chronic inflammatory disease of the colon that causes ulcers, and the study investigates the effects of a combination of Rg3-enriched Korean Red Ginseng extract (Rg3-RGE) and Pentoxifylline (PT) on UC in mice.
- The research involved multiple groups of mice treated with various substances, including a control group and those exposed to inflammatory agents, to measure outcomes like colon length, body weight, and levels of inflammatory markers.
- Results showed that the combination treatment of Rg3-RGE and PT significantly improved colon health, reduced inflammation, and enhanced immune cell function compared to the inflammatory model group, indicating its potential as a therapeutic option for UC.