Clinical investigation of use of an antimicrobial peptide hydrogel wound dressing on intact skin.

A material with the ability to rapidly eradicate bacteria via a contact-killing mechanism has the benefit of a more localised treatment that is easy to implement when needed to prevent or treat a bacterial infection. Here, we present an antimicrobial material based on covalently attached antimicrobial peptides (AMPs) to a soft amphiphilic hydrogel. This results in a material that exhibits an antimicrobial effect based on contact-killing.

Cross-linked lyotropic liquid crystal particles functionalized with antimicrobial peptides.

Antimicrobial peptides (AMPs) are promising alternatives to traditional antibiotics for addressing bacterial infections - including life-threatening antibiotic resistant infections. AMPs have a broad spectrum of antimicrobial activity and show a low probability to induce resistance. However, the poor serum stability of AMPs has limited their usage in clinical treatment.

Antimicrobial Peptide-Functionalized Mesoporous Hydrogels.

Antimicrobial peptides (AMPs) are seen as a promising replacement to conventional antibiotics for the prevention of skin wound infections. However, due to the short half-life of AMPs in biological environments, such as blood, their use in clinical applications has been limited. The covalent immobilization of AMPs onto suitable substrates is an effective solution to create contact-killing surfaces with increased long-term stability.

Osseointegration effects of local release of strontium ranelate from implant surfaces in rats.

Background: Numerous studies have reported the beneficial effects of strontium on bone growth, particularly by stimulating osteoblast proliferation and differentiation. Thus, strontium release around implants has been suggested as one possible strategy to enhance implant osseointegration.

Aim: This study aimed to evaluate whether the local release of strontium ranelate (Sr-ranelate) from implants coated with mesoporous titania could improve bone formation around implants in an animal model.

Development of a photon induced drug-delivery implant coating.

A thin surface coating intended for medical devices such as implants where local drug release is enabled using near infrared light (NIR) as an external stimulus has been developed. The delivery system consists of a thin Poly (N-isopropylacrylamide)-co-acrylamide (PNIPAAm-AAm) polymer layer with incorporated gold nanorods (GNRs). The aspect ratio of the GNRs were chosen to absorb NIR light, thus fitting the biological window of low tissue absorption, to locally heat the polymeric layer to initiate a drug release.

Antibiofilm elastin-like polypeptide coatings: functionality, stability, and selectivity.

Antimicrobial peptides (AMPs) are currently receiving interest as an alternative to conventional antibiotics to treat biomaterial-associated infection. However, the inherent instability of such peptides often limits their efficacy in intended clinical applications. Covalent immobilization of AMPs to surfaces is one strategy to increase the long-term stability and minimize the toxicity.

Stem cell homing using local delivery of plerixafor and stromal derived growth factor-1alpha for improved bone regeneration around Ti-implants.

Triggering of the early healing events, including the recruitment of progenitor cells, has been suggested to promote bone regeneration. In implantology, local drug release technologies could provide an attractive approach to promote tissue regeneration. In this study, we targeted the chemotactic SDF-1α/CXCR4 axis that is responsible e.

Modulation of the nanometer pore size improves magnesium adsorption into mesoporous titania coatings and promotes bone morphogenic protein 4 expression in adhering osteoblasts.

Objective: Mesoporous (MP) titania films used as implant coatings have recently been considered as release systems for controlled administration of magnesium to enhance initial osteoblast proliferation in vitro. Tuning of the pore size in such titania films is aimed at increasing the osteogenic potential through effects on the total loading capacity and the release profile of magnesium.

Methods: In this study, evaporation-induced self-assembly (EISA) was used with different structure-directing agents to form three mesoporous films with average pore sizes of 2nm (MP1), 6nm (MP2) and 7nm (MP3).

Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release.

Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants.

Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy.

The osseointegration capacity of bone-anchoring implants can be improved by the use of drugs that are administrated by an inbuilt drug delivery system. However, to attain superior control of drug delivery and to have the ability to administer drugs of varying size, including proteins, further material development of drug carriers is needed. Mesoporous materials have shown great potential in drug delivery applications to provide and maintain a drug concentration within the therapeutic window for the desired period of time.