Melatonin affects the expression of microRNA-21: A mini-review of current evidence.

Melatonin (MLT) is an endogenous hormone produced by pineal gland which possess promising anti-tumor effects. Anti-inflammatory and anti-oxidant properties of MLT, along with its immunomodulatory, proapoptotic, and anti-angiogenic properties, are often referred to the main mechanisms of its anti-tumor effects. Recent evidence has suggested that epigenetic alterations are also involved in the anti-tumor properties of MLT.

MicroRNA and gynecological cancers: Focus on miR-195.

Different cancer types have been shown to have down-regulated expression levels of miR-195 as an anti-tumor agent. MiR-195 family members can inhibit cancer cell proliferation, angiogenesis, epithelial-mesenchymal transition and metastases, immunosuppression, glycolysis, drug resistance, and cancer stem cell development by targeting the 3'-UTR of the mRNA of different pro-tumor genes. MiR-195 identified as a tumor suppressor miR in a variety of cancers, most notably gynecological malignancies such as cervical, endometrial, and ovarian carcinoma.

The efficacy and safety of subcutaneous continuous local infiltration analgesia with ropivacaine in patients undergoing total knee arthroplasty: a comparative study.

Background: Continuous local infiltration analgesia (CLIA) can be administered via intraarticular or periarticular techniques in patients undergoing total knee arthroplasty (TKA). The purpose of this investigation was to retrospectively report a single-center experience of epidural analgesia with subcutaneous CLIA versus epidural analgesia without CLIA among patients undergoing TKA.

Methods: This single-center retrospective study was conducted in Saudi Arabia.

Diagnosis of glomus tumor of the elbow: A case report.

Introduction: Glomus tumors are rare and often benign vascular lesions that present classically in the subungual region of the hand. Nonetheless, presentations in atypical sites have been reported over the years. However, the classic symptoms of typical glomus tumors are often absent in tumors of atypical sites.

The correlation between emotional intelligence and self-esteem in patients with intestinal stoma: A descriptive-correlational study.

Aim: Patients with intestinal stoma would experience some periods of psychological disorders such as self-esteem disturbances. Self-esteem is one of the most important factors affecting the patient's mental health. It is suggested that factors such as emotional intelligence could be related to self-esteem.

The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation.

Human glioblastoma (GBM) is the most common primary malignant brain tumor. A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY).

Venous thromboembolism prevention protocol for adapting prophylaxis recommendations to the potential risk post total knee replacement: a randomized controlled trial.

Background: Total knee replacement (TKR) is a major orthopedic surgery that is considered high risk for the development of venous thromboembolism (VTE).

Objective: The aim of this study is to evaluate the clinical outcomes that resulted from the use of a new proposed VTE risk stratification protocol for selecting a suitable extended VTE prophylaxis for post TKR surgery patients administered in conjunction with patient education programs.

Method: A randomized controlled trial was conducted in two medical centers in Saudi Arabia.

Correlation between self-efficacy and self-esteem in patients with an intestinal stoma.

Background: Patients with an intestinal stoma experience psychological difficulties, including disturbances in self-efficacy and self-esteem. There is evidence that they are interdependent.

Aim: This study aimed to determine the correlation between self-efficacy and self-esteem in patients with an intestinal stoma.

The interactional behaviors and photo-physical properties of azo-salicylaldehyde ligands in solvents media.

A quantitative study of solvent effects on photo-physical properties of some azo-salicylaldehyde Schiff Bases ligands, with various substituent and alkyl group, was carried out, at room temperature. The solvatochromic behavior of these substances and their solvent-solute interactions, both specific and non-specific, was analyzed using linear solvation energy relationship concept, suggested by Kamlet-Taft. The ground and excited state dipole moments of these substances and their molecular resonance structures were also evaluated via solvatochromic shift method.

Distraction osteogenesis using a longitudinal corticotomy.

Purpose: The purpose of this study was to evaluate whether the use of a longitudinal corticotomy (S-Z osteotomy) results in more rapid consolidation following distraction osteogenesis of short tibiae.

Methods: Sixty-seven lengthening procedures were performed in 51 patients ranging in age from nine to 38 (mean 25) years. Diagnoses included short stature (32 tibiae), postpolio limb deformity (22 tibiae), osteomyelitis (three tibiae), trauma (two tibiae) and other diagnoses (eight tibiae).

The anterolateral ligament of the human knee: an anatomic and histologic study.

Purpose: The functional anatomy of the knee is frequently studied but remains incompletely understood. Numerous authors have described a structure in the lateral knee connecting the lateral femoral condyle with the lateral meniscus and tibial plateau. The goal of this study is to define the incidence, anatomy, and histology of this structure, the anterolateral ligament.

"PAF" analysis of acute distal radius fractures in adults. Preliminary results.

There is not enough evidence in the literature to support the use of any treatment in distal radius fractures, mainly because of the heterogeneous aspects of most series. There is a need for more standardized analyses of distal radius fractures that should allow the identification of more homogeneous groups of patients. The authors propose a novel synthetic method to analyse acute distal radius fractures in adults.

[Intra-articular sub-periosteal osteoid osteoma of the triquetrum. Case report].

We report a case of subperiosteal osteoid osteoma of the triquetrum located into the piso-triquetral joint space. Such a variant at this particular location is very rare. The diagnosis was delayed for six years.

[Analysis of acute distal radius fractures with the articular sagittal index (ASI)].

Displacements of articular fragments are not always visible on initial radiographs of acute distal radius fractures. Despite the wide use of CT scan, it may be useful to know a simple index that could suggest an articular displaced fracture from the initial standard radiographs. The authors describe an articular sagittal index (ASI) of the distal radius and provide reference values from a study of 100 healthy volunteers.