Publications by authors named "Saarang R Deshpande"

Article Synopsis
  • AAV-based gene therapy shows promising results for treating severe hemophilia A (HA) and hemophilia B (HB) in adult males, with studies indicating a significant reduction in annualized bleeding rates (ABR) and infusion rates (AIR).
  • In hemophilia A, gene therapy led to an average decrease of 7.58 bleeding events and 117.2 factor infusions annually, while hemophilia B saw reductions of 5.64 bleeding events and 58.92 infusions.
  • While both therapies resulted in favorable outcomes, factor expression durability was better in HB compared to HA, with serious adverse events reported in about 19-21% of subjects but no cases of thrombosis or inhibitor
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Objective: There are significant inequities in colorectal cancer (CRC) screening and outcomes. Via literature review, we assessed CRC screening rates for the vulnerable populations served by free clinics.

Methods: A systematic review was conducted for publications on CRC screening in free clinics.

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Purpose: Letters of recommendations (LORs) are key components of academic medicine applications. Given that bias against students and trainees underrepresented in medicine (UIM) has been demonstrated across assessment, achievement, and advancement domains, the authors reviewed studies on LORs to assess racial, ethnic, and UIM differences in LORs. Standardized LORs (SLORs), an increasingly common form of LORs, were also assessed for racial and ethnic differences.

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Purpose: Stereotactic body radiation therapy (SBRT) is considered the standard of care for medically inoperable early-stage non-small cell lung cancer. There is mixed evidence on the prognostic significance of tumor metabolic activity assessed by positron emission tomography combined with computed tomography (PET/CT) using F-18 fluorodeoxyglucose (FDG). The objectives of this study were to evaluate the maximum standardized uptake value (SUV) pretreatment and at 3 and 6 months after SBRT for prediction of tumor control and survival outcomes.

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Purpose: Stereotactic body radiation therapy (SBRT) has become the standard of care for medically inoperable early-stage non-small cell lung cancer. We investigated 2 modalities of lung SBRT, CyberKnife (CK) and volumetric modulated arc therapy (VMAT), for differences in dosimetric parameters, tumor control, and clinical outcomes.

Methods And Materials: Patients who underwent SBRT for T1-2N0M0 non-small cell lung cancer from 2012 to 2018 were included.

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Multiple myeloma is the second most common hematologic malignancy and remains incurable. Patients who fail multiple lines of therapy typically have a poor prognosis despite recent advances in myeloma treatment. Chimeric antigen receptor T (CAR T) cell treatment has emerged as a promising therapy for many hematologic malignancies, including recently approved and emerging applications for myeloma treatment.

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