Publications by authors named "Saara Wahlroos"
Article Synopsis
- The study focused on how the density of synapses in the hippocampus relates to amyloid beta and cognitive performance in healthy individuals who carry the APOE ε4 gene.
- Researchers found that APOE ε4/ε4 carriers had significantly lower synaptic density compared to APOE ε3/ε3 carriers, indicating early synaptic loss in those at risk for Alzheimer's disease.
- Despite the differences in synaptic density, there was no correlation found between synaptic density and cognitive performance measures, suggesting that cognitive decline may not yet be evident in these individuals.
Background: P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [C]SMW139 is the most recently developed radiotracer to image P2X7 receptor. The aim of this study was to image reactive glia in the APP/PS1-21 transgenic (TG) mouse model of Aβ deposition longitudinally using [C]SMW139 targeting P2X7 receptor and to compare tracer uptake to that of [F]F-DPA targeting TSPO at the final imaging time point.
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- This study aimed to investigate the activation of brain innate immune cells in patients with relapsing-remitting multiple sclerosis who were treated with teriflunomide for six months.
- Researchers used advanced imaging techniques, including TSPO-PET and MRI, to assess microglial activity, lesion load, and brain volume in 12 patients compared to 12 healthy controls.
- Results showed that treated patients had slightly higher innate immune cell activation but no significant changes over time, suggesting minimal inflammation related to lesions and highlighting the study's novel approach in using both imaging methods for evaluation.
The membrane-based purinergic 7 receptor (P2XR) is expressed on activated microglia and the target of the radioligand [C]SMW139 for assessment of neuroinflammation. This study investigated the contribution of radiolabelled metabolites which potentially affect its quantification. high-performance liquid chromatography with a radio detector (radioHPLC) was used to evaluate the parent and radiometabolite fractions of [C]SMW139 in the brain and plasma of eleven mice.
View Article and Find Full Text PDFRadiometabolites of PET tracers interfere with imaging and need to be taken into account when modeling PET data. Various tracer and radiometabolite characteristics affect the uptake rate into tissue. In this study, we investigated two such factors, lipophilicity and protein-free fraction.
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