Preparation of a radiolabeled GnRH-I analogue derivative with In as a new anti-proliferative agent.

The new GnRH-Ιanalogue developed in this paper was based on the D-Trp -GnRH-Ι-scaffold, and its potency was increased by the replacement Gly-NH by NH-NH binding to the Gly at position 10. Triptorelin-Hydrazide analogue was synthesized using solid phase. For In labeling, synthesized peptide was followed by conjugation with DOTA using pSCN-Bn-DOTA.