Effect of the intrinsic and extrinsic factors on the growth and development of young foals under subtropical conditions of Pakistan.

This study was designed to explore the impact of intrinsic (breed of foal, age of dam, and age of foal at weaning) and extrinsic (season of birth and housing type) factors on the growth and survival of foals in the subtropical conditions of Pakistan. For the growth study, retrospective data analysis of foals (n = 150) born from purebred brood mares of Thoroughbred, Arabs, and Percheron breeds (n1, n2, and n3 = 50 each) was made. Six hundred and twenty-four (n = 624) foals born between 2020 to 2022 were observed for the study of foal survival rate.

Exploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil.

Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with rheumatism, gastric disorders, and as an analgesic. Chemo-herbal combinations are known to have potent anti-inflammatory and analgesic effects, while mitigating the drug related side effects.

Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson's disease model through the modulation of neuroinflammatory markers.

The plant Cissus tuberosa Moc is abundant in phenolics, has been documented to have neuroprotective properties. The study seeks to determine the neuroprotective effects of C. tuberosa ethanolic extract (CTE) against Parkinson's disease by evaluating its impact on motor dysfunction, cognitive deficits, neuroinflammation, and neurodegeneration in paraquat-induced Parkinson's disease models.

Unlocking the effect of film thickness on the thermoelectric properties of thermally evaporated Cu Se thin films.

Miniaturization is crucial to realize thermoelectric (TE) devices as an energy source for smart utilities. The present work reports the bulk-like value realized in Cu Se thin films in the mid-temperature range. The effect of varying the film thickness on the structural and TE properties were systematically studied, and the obtained results were compared with that of their bulk counterpart.

Exploration of neuroprotective and cognition boosting effects of in Alzheimer's disease model.

Objectives: (MP) an Asian flowering plant, known for various reported pharmacological activities including antioxidant, anti-nociceptive, anti-inflammatory, anticancer, antibacterial, antifungal, and hepatoprotective effects. This study focused on further exploring s methanol leaf extract (MPM) for bioactive principles and investigating its neuroprotective and cognition-enhancing potential in Alzheimer's disease models.

Methods: For the phytochemical screening and identification, TLC, HPLC, and Fourier transform infrared (FTIR) were employed.

Quantitative analysis of loxoprofen sodium loaded microspheres comprising pectin and its thiolated conjugates: evaluation of their sustained release behavior.

Continuous use of oral NSAIDs can damage mucosal membrane, which results in decreased bioavailability and non-compliance with the therapy. But the use of sustained release drug delivery systems might offer a solution. Objective was to synthesize mucoadhesive SR microspheres by using different combinations of pectin (PEC) and its thiolated derivative (T-PEC3100) for improved loxoprofen (LS) permeation.

Preovulatory follicular dynamics and ovulatory events following the use of GnRH 84 h after medroxyprogesterone acetate sponge removal in postpartum buffaloes.

Herein, we evaluated the effects of gonadotropin hormone-releasing hormone (GnRH) administration 84 h after medroxyprogesterone acetate (MAP) sponge removal on follicular growth, ovulation timing, and pregnancy per artificial insemination (AI) in cosynchronized postpartum Nili Ravi buffaloes. In this study, 58 Nili Ravi postpartum buffaloes (DIM = 103 ± 1.64) were randomly divided into two treatment groups (n = 29/treatment): GnRH-TAI-84 and TAI-84.

Synthesis and Characterization of Chemically and Green-Synthesized Silver Oxide Particles for Evaluation of Antiviral and Anticancer Activity.

Silver oxide (AgO) particles are wonderful candidates due to their unique properties, and their use in a wide range of research, industrial and biomedical applications is rapidly increasing. This makes it fundamental to develop simple, environmentally friendly methods with possible scaling. Herein, sodium borohydride and leaf extract were applied as chemical and biological stabilizing and reducing agents to develop AgO particles.

Biochemical properties and biological potential of Syzygium heyneanum with antiparkinson's activity in paraquat induced rodent model.

Syzygium heyneanum is a valuable source of flavonoids and phenols, known for their antioxidant and neuroprotective properties. This research aimed to explore the potential of Syzygium heyneanum ethanol extract (SHE) in countering Parkinson's disease. The presence of phenols and flavonoids results in SHE displaying an IC50 value of 42.

Phytochemical and biological studies of aerial parts ethanol extract supported by molecular docking study.

has traditionally been used as a poultice to alleviate local inflammation and painful diseases. This study aimed to evaluate the anti-inflammatory, wound-healing, analgesic, and antipyretic potential of its ethanol extract (PAAPEE) for the first time. antioxidant assays of using a 2,2-diphenyl-1-picrylhydrazyl assay revealed that it showed IC of 62.

Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate.

Depression is the major mental illness which causes along with loss of interest in daily life, a feeling of hopelessness, appetite or weight changes, anger and irritability. Due to the hepatic first-pass metabolism, the absolute bioavailability of fluvoxamine (FVM) after oral administration is about 50%. By avoiding the pre-systemic metabolism, nasal delivery would boost bioavailability of FVM.

Molecular identification and infection pathology of Mycobacterium spp. in captive wild animals in Pakistan.

Introduction: Animal tuberculosis is an infectious, chronic, granulomatous, and debilitating disease affecting animals as well as humans. However, in recent decades, there have been many endemic geographic localities where animal tuberculosis has been identified in wildlife reservoirs, limiting the eradication program in cattle. This study aimed to identify animal tuberculosis in captive zoo animals in Pakistan.

Comparative evaluation of ethyl acetate and n-Hexane extracts of L. leaves for muscle function restoration after peripheral nerve lesion.

Peripheral nerve injuries are one of those complex medical conditions for which a highly effective first-line treatment is currently missing. The use of natural compound as medicines to treat various disorders has a long history. Our previous research explored that crude L.

Antibacterial Efficacy of -(4-methylpyridin-2-yl) Thiophene-2-Carboxamide Analogues against Extended-Spectrum-β-Lactamase Producing Clinical Strain of ST 131.

Development in the fields of natural-product-derived and synthetic small molecules is in stark contrast to the ongoing demand for novel antimicrobials to treat life-threatening infections caused by extended-spectrum β-lactamase producing (ESBL ). Therefore, there is an interest in the antibacterial activities of synthesized -(4-methylpyridin-2-yl) thiophene-2-carboxamides (-) against ESBL-producing ST131 strains. A blood sample was obtained from a suspected septicemia patient and processed in the Bactec Alert system.

Correction to Therapeutic Potential of Standardized Extract of (L.) All. and Its Phytochemicals against Skin Cancer in Animal Model: , , and Studies.

[This corrects the article DOI: 10.1021/acsomega.2c03053.

Dose Dependent Effects of Against the Paraquat Induced Parkinsonism like Symptoms in Animals' Model: , and Mechanistic Studies.

The aims and objectives of the study were to evaluate the antiParkinson's (PD) potential of (BCE). (Poir.) Müll.

Molecular Modeling Study of Novel Bioactive Molecule as an Inhibitor of Acetylcholinesterase (AChE), Herpes Simplex Virus (HSV-1), and Anti-proliferative Proteins.

, an immense family involving species (500) or genera (20), originates in tropical and subtropical regions. This family has evinced medicinal values such as anti-leishmanial, cytotoxic, antibacterial, antidiabetic, antiprotozoal, and antifungal properties. methanol extract (CLM) was prepared, then compound isolation performed by open column chromatography, and compound structure was determined by spectroscopic techniques (C NMR, IR spectroscopy, H-NMR, mass spectrometry UV-visible, and 2D correlation techniques).

Therapeutic Potential of Standardized Extract of (L.) All. and Its Phytochemicals against Skin Cancer in Animal Model: , , and Studies.

(L.) All. is known to have anti-inflammatory and anticancer properties.

Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections.

The occurrence of fungal infections has increased over the past two decades. It is observed that superficial fungal infections are treated by conventional dosage forms, which are incapable of treating deep infections due to the barrier activity possessed by the stratum corneum of the skin. This is why the need for a topical preparation with advanced penetration techniques has arisen.

A Novel Distachionate from Treats Inflammations by Modulating COX-2 and Inflammatory Cytokines in Rat Liver Tissue.

Breynia distachia is a plant of genus Breynia belonging to family Phyllanthaceae. This study was conducted to isolate and examine the anti-inflammatory attributes of the roots of Breynia distachia. Methanol extract from roots were prepared by simple maceration.

Verapamil attenuates oxidative stress and inflammatory responses in cigarette smoke (CS)-induced murine models of acute lung injury and CSE-stimulated RAW 264.7 macrophages via inhibiting the NF-κB pathway.

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), severe form of ALI, are characterized by overwhelming of lung inflammation, and no treatment is currently available to treat ALI/ARDS. Cigarette smoke (CS) is one of the prime causes to induce ALI/ARDS via oxidative stress. Despite extensive research, no appropriate therapy is currently available to treat ALI/ARDS.

Revamping of Chronic Respiratory Diseases in Low- and Middle-Income Countries.

Low- and middle-income countries (LMICs) endure an asymmetrically high burden of worldwide disease and death caused by chronic respiratory diseases (CRDs), i.e., asthma, emphysema, bronchiectasis, and post-tuberculosis lung disease (PTLD).

Pharmacological Justification for the Medicinal Use of Linn. in Cardiovascular Disorders.

(L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of in cardiovascular illnesses and its underlying mechanisms.

Acute Respiratory Distress Syndrome and COVID-19: A Literature Review.

Acute respiratory distress syndrome (ARDS) is an overwhelming inflammatory disorder of the lung due to direct and indirect insults to the lungs. ARDS is characterized by increased vascular permeability, protein-rich edema, diffuse alveolar infiltrate, and loss of aerated lung tissue, leading to decreased lung compliance, tachypnea, and severe hypoxemia. COVID-19 is generally associated with ARDS, and it has gained prime importance since it started.