Baker's Yeast Induces Apoptotic Effects and Histopathological Changes on Skin Tumors in Mice.

The current study investigates the apoptotic effect of Baker's yeast () on chemically-induced skin cancer in mice. Intra-tumoral treatment with yeast caused: increases in Ca in skin homogenate, modulated the intrinsic/extrinsic pathways by downregulating Bcl-2 and FasL, upregulating Bax, and increased the expression of cytochrome-c and caspases 9, 8, and 3. Histopathological changes were detected, including mild dysplasia, atypia, tumor regression, and absence of basaloid cell proliferation.