Huntington's Disease: Latest Frontiers in Therapeutics.

Purpose Of Review: Huntington's disease (HD) is an autosomal-dominant disorder caused by a pathological expansion of a trinucleotide repeat (CAG) on exon 1 of the huntingtin (HTT) gene. HD is characterized by the presence of chorea, alongside other hyperkinesia, parkinsonism and a combination of cognitive and behavioural features. Currently, there are no disease-modifying therapies (DMTs) for HD, and the only intervention(s) with approved indication target the treatment of chorea.

LASIK Videos on TikTok: A Content Analysis of the Top 100 Videos.

Introduction: Social media has increasingly become a prominent source of health information. Platforms like TikTok that allow for videos to reach millions of viewers have become among the most common platforms to share and receive health information. Laser in situ keratomileusis (LASIK) videos and patients' experiences are commonly discussed on social media.

Corneal Deposits: A Presentation of Arthrobacter Keratitis.

Introduction: Infectious keratitis, an inflammatory condition of the cornea, poses a significant public health concern globally. Bacterial keratitis, the most common type, primarily involves and . Timely diagnosis and treatment are crucial to prevent vision loss.

Performance of ChatGPT on Ophthalmology-Related Questions Across Various Examination Levels: Observational Study.

Background: ChatGPT and language learning models have gained attention recently for their ability to answer questions on various examinations across various disciplines. The question of whether ChatGPT could be used to aid in medical education is yet to be answered, particularly in the field of ophthalmology.

Objective: The aim of this study is to assess the ability of ChatGPT-3.

Society of skeletal radiology position paper - recommendations for contrast use in musculoskeletal MRI: when is non-contrast imaging enough?

The following White Paper will discuss the appropriateness of gadolinium administration in MRI for musculoskeletal indications. Musculoskeletal radiologists should consider the potential risks involved and practice the judicious use of intravenous contrast, restricting administration to cases where there is demonstrable added value. Specific nuances of when contrast is or is not recommended are discussed in detail and listed in table format.

A Modified Technique for Induced Gingival Growth Around Compromised Teeth Prior to Implant Placement: A Report of Two Cases.

Regenerative and reconstructive periodontal plastic surgery are important options for treating marginal tissue recession and can be indicated for root coverage or periodontal procedures prior to implant placement. Among the available procedures, periodontal flaps with subepithelial connective tissue graft (CTG) is the most common treatment option to achieve proper tissue manipulation. The present study proposes a modification of a previous technique for inducing spontaneous gingival growth around teeth that will be extracted prior to implant placement, through successive reduction of the buccal root surface.

Supporting parenting among Syrian refugees in Lebanon: a randomized controlled trial of the caregiver support intervention.

Background: Parenting interventions in humanitarian settings have prioritized the acquisition of parenting knowledge and skills, while overlooking the adverse effects of stress and distress on parenting-a key mediator of refugee children's mental health. We evaluated the effectiveness of the Caregiver Support Intervention (CSI), which emphasizes caregiver wellbeing together with training in positive parenting.

Methods: We conducted a two-arm randomized controlled trial of the CSI with Syrian refugees in Lebanon, with an intent-to-treat design, from September 2019-December 2020.

Effect of self-assessment in a removable prosthodontics preclinical course on skills and competence.

Purpose: Self-assessment is increasingly implemented in medical professions' curricula. In this research, the authors measure the effects of self-assessment within a preclinical removable prosthodontics course among dental students in a private dental school according to the European qualifications framework descriptors.

Materials And Methods: Thirty subjects, all fourth-year dental students, were included in this experiment.

Bromfenac 0.09% for the Treatment of Macular Edema Secondary to Noninfectious Uveitis.

Purpose: The topical nonsteroidal anti-inflammatory drug bromfenac 0.09% has a potential benefit in uveitic macular edema (UME) with a safe side effect profile. The aim of the study is to assess the efficacy of bromfenac sodium solution in the treatment of UME.

Analysis of Monoclonal Antibody Glycopeptides by Capillary Electrophoresis-Mass Spectrometry Coupling (CE-MS).

Glycosylation is a crucial posttranslational modification (PTM) that might affect the safety and efficacy of monoclonal antibodies (mAbs). Capillary electrophoresis-mass spectrometry (CE-MS) enables the characterization of the primary structure of mAbs. A bottom-up proteomic workflow is designed to provide detailed information about the glycosylation.

Perceived Surgeon Stress During No-Sedation Topical Phacoemulsification.

Purpose: To determine the patient-related factors that contribute to surgeon stress during phacoemulsification cataract extraction (PCE) performed under unassisted topical anesthesia.

Methods: This is a prospective study of perceived surgeon stress during phacoemulsification by a single surgeon of consecutive patients undergoing PCE. At the conclusion of each procedure, the surgeon recorded the perceived stress according to the following three indices: surgeon score, qualitative score (yes or no), and total score (sum of itemized causes of stress).

Strengthening parenting in conflict-affected communities: development of the Caregiver Support Intervention.

Background: There is robust evidence that compromised parenting, stemming from persistently high stress, mediates the impact of war and displacement on children's mental health and psychosocial wellbeing. Parenting interventions generally prioritize the acquisition of parenting knowledge and skills, while under-attending to parental stress and distress. This paper describes the development of the Caregiver Support Intervention (CSI), a nine-session group intervention for conflict-affected parents of children aged 3-13, that aims to strengthen parenting both indirectly, by lowering stress and improving psychosocial wellbeing among parents, and directly, by increasing knowledge and skill related to positive parenting.

Evaluation Of The Effect Of Different Surface Treatments, Aging And Enzymatic Degradation On Zirconia-Resin Micro-Shear Bond Strength.

Purpose: The purpose of this study was to evaluate the effect of surface treatments on zirconia-resin bonding and the effect of aging on bond durability for one year.

Method: Three hundred and twenty zirconia blocks were divided into 4 equal study groups. Group 1 (control): as-sintered, group 2: (GB): grit-blasted, group 3: (LAS): laser-etched, group 4: (SIE): selective infiltration etching.

Prospective assessment of the effectiveness of autonomous emergency braking in car-to-cyclist accidents in France.

This study aimed to assess the effectiveness of autonomous emergency braking (AEB) systems in car-to-cyclist frontal collisions by simulating their effects, in terms of crash avoidance and injury mitigation, on a representative target population of real-world accidents. Identifying effectiveness-critical AEB-cyclist design parameters through a sensitivity analysis was also targeted. The analysis is based on a representative set of real-world car-to-cyclist frontal collisions gathered from French police reports.

Bipolar clavicular fracture on ipsilateral reverse shoulder prosthesis: Case report.

Background: Bipolar clavicular fractures are extremely rare with no consensus on management. No previous cases of bipolar clavicular fracture on an ipsilateral reverse shoulder prosthesis have been reported.

Case Presentation: We report a case of a 78y.

Nontraumatic Epithelial Ingrowth 15 Years Post Laser In Situ Keratomileusis.

Epithelial ingrowth occurring many years after primary Laser in Situ Keratomileusis (LASIK) without a preceding traumatic event is very rare. We describe the case of a 61-year-old woman with epithelial ingrowth in her right eye 15 years after primary LASIK. She presented with right eye redness, pain, and decreased vision and denied any preceding trauma.

Characterization of the Primary Structure of Cysteine-Linked Antibody-Drug Conjugates Using Capillary Electrophoresis with Mass Spectrometry.

Capillary electrophoresis-mass spectrometry (CE-MS) enables the characterization of the primary structure of ADCs. An analytical method based on a derived bottom-up proteomic workflow is designed to provide detailed information about the amino acid sequence, the glycosylation profiling, and the location on the peptide backbone of the conjugated drugs. Here we describe the experimental protocol applied on the characterization of cysteine-linked brentuximab vedotin (Adcetris).

Effect of different combinations of surface treatment on adhesion of resin composite to zirconia.

The purpose of this laboratory study was to evaluate the effect of different surface treatment combinations on resin zirconia bonding. One hundred and five pre-sintered zirconia quadrangles were prepared out of zirconia blocks, polished, then sintered and divided into five groups (n=21). Group I (control): samples were untreated, group II: grit-blasting with 50 µm alumina particles, group III: grit-blasting with 100 µm alumina particles, group IV: Er,Cr:YSGG laser, and group V: selective infiltration etching technique.

Isolated traumatic pectoralis minor tendon tear in a young adult diagnosed with MRI.

This is a rare case of an isolated pectoralis minor partial-thickness tendon tear in a 24-year-old man who was involved in a major trauma. The purpose of this paper is to report the clinical signs, symptoms, cross-sectional imaging findings, and management of an isolated pectoralis minor tendon tear. Furthermore, this case represents a novel traumatic mechanism of injury, as opposed to the classic sports-related pectoralis minor tendon tear injury.

Instability of TCF4 Triplet Repeat Expansion With Parent-Child Transmission in Fuchs' Endothelial Corneal Dystrophy.

Purpose: Fuchs' endothelial corneal dystrophy (FECD) caused by the CTG triplet repeat expansion in the TCF4 gene (CTG18.1 locus) is the most common repeat expansion disorder. Intergenerational instability of expanded repeats and clinical anticipation are hallmarks of other repeat expansion disorders.

Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center.

Background/aims: Preterm newborns with a very low birth weight (VLBW) of < 1,500 g have an atypical form of hypothyroidism with a delayed rise in TSH, necessitating a second newborn screening specimen collection. The aims of this study were to survey the compliance with second newborn screening to detect delayed TSH rise in VLBW preterm infants at a tertiary care center, and to determine the rate of atypical hypothyroidism.

Methods: Retrospective review of the records of 104 preterm VLBW infants.