Publications by authors named "Saadat Kamran"

Purpose: To assess whether corneal nerve analysis can identify and differentiate patients with multiple sclerosis (MS) from those with epilepsy.

Methods: Participants with MS (n = 83), participants with epilepsy (n = 50), and healthy controls (HCs) (n = 20) underwent corneal confocal microscopy (CCM) and quantification of automated corneal nerve fiber length (ACNFL), automated corneal nerve fractal dimension (ACNFrD), and ACNFrD/ACNFL ratio of the subbasal nerve plexus.

Results: ACNFL (MS: P < 0.

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Objectives: Functional outcomes in patients with intracerebral hemorrhage (ICH) have not been well characterized in the Middle East and North Africa Region. We report the 30 and 90-day clinical outcomes in the native and expatriate of Qatar with ICH.

Methods: We evaluated the Glasgow Coma Scale (GCS), NIHSS, and imaging in the Qatar Stroke Registry (2013-22).

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Article Synopsis
  • - The study analyzes stroke prevalence and risk factors in Qatar from January 2014 to September 2020, revealing that a significant portion of patients were diagnosed with ischemic stroke and had common risk factors like hypertension and diabetes.
  • - Out of nearly 12,000 patients analyzed, most were young, predominantly Asian and Arab men, with a median age of 52 years; emergency treatment for stroke was commonly received within 4.5 hours but only a small percentage underwent advanced interventions like thrombolysis.
  • - The findings suggest that stroke in Qatar reflects unique demographic and health challenges, indicating a need for tailored prevention and management strategies to address the rising incidence of stroke in this diverse population.
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Background And Objectives: Hypertriglyceridemia (HT) may increase the risk of stroke. Limited studies have shown that stroke severity and infarction size are smaller in patients with HT. We explored the relationship between triglyceride levels and stroke risk factors, severity and outcome in a large prospective database.

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Background: Posterior cerebral circulation ischemic stroke (PCS) comprises up to 25% of all strokes. It is characterized by variable presentation, leading to misdiagnosis and morbidity and mortality. We aim to describe PCS in large multiethnic cohorts.

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Background: Corneal immune cells (ICs) are antigen-presenting cells that are known to increase ocular and systemic inflammatory conditions.

Objective: We aimed to assess longitudinal changes in corneal IC in patients with multiple sclerosis (MS) and relation to disability and ongoing treatment.

Design: Prospective observational study conducted between September 2016 and February 2020.

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Objective: Cognitive impairment is a potential drawback of antiseizure medications. This study aimed to evaluate the impact of different levetiracetam drug regimens on cognitive function.

Methods: A retrospective analysis identified 221 patients diagnosed with seizures who underwent cognitive screening.

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Ischemic stroke, a severe medical condition triggered by a blockage of blood flow to the brain, leads to cell death and serious health complications. One key challenge in this field is accurately predicting infarction growth - the progressive expansion of damaged brain tissue post-stroke. Recent advancements in artificial intelligence (AI) have improved this prediction, offering crucial insights into the progression dynamics of ischemic stroke.

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Purpose: To investigate the safety and effectiveness of rescue stent placement in patients who experienced acute stroke in whom mechanical thrombectomy failed.

Methods: This was a retrospective review of a multiethnic stroke database. After stent placement, an aggressive antiplatelet protocol was followed with glycoprotein IIb/IIIa infusion.

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Objectives: There are limited data from the Middle East on sex-related differences in short- and long-term stroke outcomes. We present 8 years of experience based on the Qatar stroke database.

Setting: The Qatar stroke database prospectively collects data on all stroke patients admitted to Hamad General Hospital.

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Background: Resourceful endpoints of axonal loss are needed to predict the course of multiple sclerosis (MS). Corneal confocal microscopy (CCM) can detect axonal loss in patients with clinically isolated syndrome and established MS, which relates to neurological disability.

Objective: To assess corneal axonal loss over time in relation to retinal atrophy, and neurological and radiological abnormalities in MS.

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Article Synopsis
  • Histological structure of thrombi plays a key role in the effectiveness of recanalization therapies for acute ischemic stroke (AIS) patients, with a study analyzing 21 AIS patients.
  • Thrombi were predominantly platelet-rich, with only a small percentage containing red blood cells (RBCs), and exhibited distinct structural differences: RBC-rich areas had tightly packed RBCs and minimal von Willebrand factor (VWF), while platelet-rich areas featured thick fibrin networks, VWF, and numerous activated neutrophils.
  • The presence of neutrophil extracellular traps (NETs) was significant, as they were associated with VWF, platelets, and other inflammatory markers, indicating a complex interaction between these components in thrombus
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Article Synopsis
  • Cerebral vasospasm is a serious complication in patients with aneurysmal subarachnoid hemorrhage (aSAH), leading to high rates of disability and death, and this study aimed to identify risk factors associated with it.
  • The retrospective analysis included 259 aSAH patients, revealing that 34% experienced cerebral vasospasm, with significant associations found relating it to the severity of SAH, hypertension, and neurological deficits upon admission.
  • Treatment for hydrocephalus decreased the vasospasm risk, while endovascular treatment for aneurysms increased it, indicating the complexity and variability of risk factors in aSAH.
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BACKGROUND: The aim of this study was to assess the effectiveness of FAST stroke educational program among all preparatory school students in the state of Qatar. METHODS: The pretest-posttest experimental research design was used to evaluate the effectiveness of the FAST educational program in Qatar. A 30-minute audiovisual presentation was given to improve knowledge of stroke.

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Atraumatic convexity subarachnoid hemorrhage (cSAH) is a rare non-aneurysmal SAH, commonly due to ipsilateral internal carotid artery (ICA) stenosis. It is unusual for the cSAH to occur contralaterally to the infarct. We report two cases of acute ischemic stroke associated with contralateral and ipsilateral cSAH that had different presentations.

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Background And Purpose: Understanding the relationship of COVID-19 to stroke is important. We compare characteristics of pre-pandemic historical stroke (Pre-C), cases in acute COVID infection (Active-C) and in patients who have recovered from COVID-19 infection (Post-C).

Methods: We interrogated the Qatar stroke database for all stroke admissions between Jan 2019 and Feb 2020 (Pre-C) to Active-C (Feb2020-Feb2021) and Post-C to determine how COVID-19 affected ischemic stroke sub-types, clinical course, and outcomes prior to, during and post-pandemic peak.

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Aim: To evaluate if in patients with known diabetes, pretreatment metformin will lead to less severe stroke, better outcome, and lower mortality following acute stroke.

Methods: The Qatar stroke database was interrogated for stroke severity and outcome in patients with ischemic stroke. Outcome was compared in nondiabetic vs.

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Objectives: Pial collateral blood flow is a major determinant of the outcomes of acute ischemic stroke. This study was undertaken to determine whether retinal vessel metrics can predict the pial collateral status and stroke outcomes in patients.

Methods: Thirty-five patients with acute stroke secondary to middle cerebral artery (MCA) occlusion underwent grading of their pial collateral status from computed tomography angiography and retinal vessel analysis from retinal fundus images.

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Article Synopsis
  • Some people on airplanes are having strokes, and this is becoming an important issue to talk about.
  • Researchers studied patients who had strokes while traveling and compared them to those who didn’t travel.
  • They found that travelers with strokes were older and had more severe strokes, and they got treated more than those who stayed on the ground.
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Article Synopsis
  • * After the peak, admissions increased to an average of 192 per month, but there were more severe cases of ischemic strokes and less functional recovery observed.
  • * The decline in admissions was largely due to a reduction in cases that were not actual strokes (stroke mimics), highlighting the need for further investigation into ongoing trends even after COVID-19 cases decline.
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Understanding the relationship of COVID-19 to stroke is important. We compare characteristics of pre-pandemic stroke (PPS), cases in acute COVID infection (CS) and in patients who have recovered from COVID-19 infection (RCS). We interrogated the Qatar stroke database for all stroke admissions between Jan 2020 and Feb 2021 (PPS) to CS and RCS to determine how COVID-19 affected ischemic stroke sub-types, clinical course, and outcomes prior to, during and post-pandemic peak.

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Objectives: The long-term acute stroke outcome has not been well studied in the Middle-Eastern population. The primary objective of our study is to compare the long-term outcome of acute ischaemic stroke (IS) with/without previous cerebrovascular/cardiovascular disease (CVD) to stroke mimics (SM) with CVD.

Settings And Participants: The Qatar stroke database was reviewed for IS and SM admissions in Qatari Nationals between 2013 and 2019.

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Vascular and inflammatory mechanisms are implicated in the development of cerebrovascular disease and corneal nerve loss occurs in patients with transient ischemic attack (TIA) and acute ischemic stroke (AIS). We have assessed whether serum markers of inflammation and vascular integrity are associated with the severity of corneal nerve loss in patients with TIA and AIS. Corneal confocal microscopy (CCM) was performed to quantify corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fiber length (CNFL) in 105 patients with TIA (n = 24) or AIS (n = 81) and age matched control subjects (n = 56).

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