Design, synthesis, and unraveling the antibacterial and antibiofilm potential of 2-azidobenzothiazoles: insights from a comprehensive study.

The present study reports the synthesis of 2-azidobenzothiazoles from substituted 2-aminobenzothiazoles using sodium nitrite and sodium azide under mild conditions. All the synthesized compounds were examined for their antibacterial activity against Gram (+) bacteria, (ATCC 25923), (ATCC 51299), (ATCC 10876) and Gram (-) bacteria, (ATCC 10536), (ATCC 10145), (ATCC BAA-2146)and clinical isolates of Gram (+) Methicillin Resistant (MRSA) and Multi Drug Resistant . The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values by broth dilution method revealed that compound 2d exhibited significant antibacterial potential against and with MIC of 8 μg/mL, while other synthesized compounds had only moderate effects against all the tested species.