The efficacy of egg albumin nanoparticles adjuvanted Clostridium perfringens type D toxoid vaccine in rabbits.

Epsilon toxin (ETX) is an exotoxin produced by Clostridium perfringens type D that induces enterotoxaemia or necrotic intestinal infection in small ruminants and bovine. Immunization is an essential element in preventing the spread of infectious diseases. In recent literature, nanocarriers have exhibited the capacity to deliver protection, stability, and regulated distribution properties to protein-based antigens.

Unleashing Vanadium-Based Compounds for High-Energy Aqueous Zinc-Ion Batteries.

Rechargeable aqueous zinc-ion batteries (ZIBs) are poised as a promising solution for large-scale energy storage and portable electronic applications. Their appeal lies in their affordability, abundant materials, high safety standards, acceptable energy density, and eco-friendliness. Vanadium-based compounds stand out as potential cathode materials due to their versatile phases and variable crystal structures, empowering design flexibility to affect the theoretical capacity.

A surface modified laser-induced graphene based flexible biosensor for multiplexed sweat analysis.

The growing popularity of electrochemical sensors featuring non-invasive biosensing technologies has generated significant enthusiasm for continuous monitoring of bodily fluid biomarkers, potentially aiding in the early detection of health issues in individuals. However, detection of multiple biomarkers in complex biofluids often necessitates a high-density array which creates a challenge in achieving cost-effective fabrication methods. To overcome this constraint, this work reports the fabrication of an electrochemical sensor utilizing a NiO-TiCT MXene-modified flexible laser-induced graphene (LIG) electrode for the separate and concurrent analysis of ascorbic acid (AA), dopamine (DA), and uric acid (UA) in human sweat and also addresses the deficiencies in the existing state of the art by offering a cost-efficient and high-performance sensor that mitigates the degrading constraints of conventional LIG electrodes.

Recapitulation of Peste des Petits Ruminants (PPR) Prevalence in Small Ruminant Populations of Pakistan from 2004 to 2023: A Systematic Review and Meta-Analysis.

Peste des petits ruminants (PPR) is an extremely transmissible viral disease caused by the PPR virus that impacts domestic small ruminants, namely sheep and goats. This study aimed to employ a methodical approach to evaluate the regional occurrence of PPR in small ruminants in Pakistan and the contributing factors that influence its prevalence. A thorough search was performed in various databases to identify published research articles between January 2004 and August 2023 on PPR in small ruminants in Pakistan.

The Problem of Occult Pyelonephritis: Acute Pyelonephritis in Patients Presenting Only with Lower Urinary Tract Symptoms.

Pyelonephritis is a prevalent diagnosis of emergency department visits. It commonly presents as flank pain and costovertebral tenderness with urinary symptoms. However, some cases occur without typical symptoms.

Early Lactate Clearance as a Determinant of Survival in Patients with Sepsis: Findings from a Low-resource Country.

Background: Single lactate measurements have been reported to have prognostic significance, however, there is a lack of data in local literature from Pakistan. This study was done to determine prognostic role of lactate clearance in sepsis patients being managed in our lower-middle income country.

Methods: This prospective cohort study was conducted from September 2019-February 2020 at the Aga Khan University Hospital, Karachi.

Synthesis and Characterization of Sulfur and Sulfur-Selenium Nanoparticles Loaded on Reduced Graphene Oxide and Their Antibacterial Activity against Gram-Positive Pathogens.

Resistance to antimicrobial agents in Gram-positive bacteria has become a major concern in the last decade. Recently, nanoparticles (NP) have emerged as a potential solution to antibiotic resistance. We synthesized three reduced graphene oxide (rGO) nanoparticles, namely rGO, rGO-S, and rGO-S/Se, and characterized them using X-ray diffraction (PXRD), Raman analysis, and thermogravimetric analysis.

Frequency and risk factors of non-alcoholic fatty liver disease in -infected dyspeptic patients: A cross-sectional study.

Background: In dyspeptic patients with contributes to non-alcoholic fatty liver disease. However, little evidence available from Pakistan.

Objective: The study aims to determine the frequency and risk factors of non-alcoholic fatty liver disease in dyspeptic patients with .

Spike glycoproteins: Their significance for corona viruses and receptor binding activities for pathogenesis and viral survival.

The recent outbreak of Covid-19 is posing a severe threat to public health globally. Coronaviruses (CoVs) are the largest known group of positive-sense RNA viruses surviving on an extensive number of natural hosts. CoVs are enveloped and non-segmented viruses with a size between 80 and 120 nm.

Current Challenges of Digital Health Interventions in Pakistan: Mixed Methods Analysis.

Background: Digital health is well-positioned in low and middle-income countries (LMICs) to revolutionize health care due, in part, to increasing mobile phone access and internet connectivity. This paper evaluates the underlying factors that can potentially facilitate or hinder the progress of digital health in Pakistan.

Objective: The objective of this study is to identify the current digital health projects and studies being carried out in Pakistan, as well as the key stakeholders involved in these initiatives.

Facile Synthesis of a Z-Scheme ZnInS/MoO Heterojunction with Enhanced Photocatalytic Activity under Visible Light Irradiation.

Employing a visible-light-driven direct Z-scheme photocatalytic system for the abatement of organic pollutants has become the key scientific approach in the area of photocatalysis. In this study, a highly efficient Z-scheme ZnInS/MoO heterojunction was prepared through the hydrothermal method, followed by the impregnation technique that facilitates the formation of an interface between the two phases for efficient photocatalysis. The structural, optical, and surface elemental composition and morphology of the prepared samples were characterized in detail through X-ray diffraction, UV-vis diffuse reflectance spectra, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy.

Evaluation of use of e-Learning in undergraduate radiology education: a review.

Purpose: The aim of this review is to investigate the evaluative outcomes present in the literature according to Kirkpatrick's learning model and to examine the nature and characteristics of the e-Learning interventions in radiology education at undergraduate level.

Materials And Methods: Four databases (PubMed, MEDLINE, Embase, Eric) are searched for publications related to the application of e-Learning in undergraduate radiology education. The search strategy is a combination of e-Learning and Mesh and non Mesh radiology and undergraduate related terms.