Publications by authors named "Saad Tauheed Rao"
J Sleep Res
December 2024
Article Synopsis
- Patients with isolated rapid eye movement sleep behavior disorder (iRBD) show abnormal accumulation of misfolded alpha-synuclein protein, which may help identify this early stage of neurodegenerative diseases.
- A meta-analysis of 15 studies found that testing for phosphorylated alpha-synuclein (p-syn) in skin samples is more accurate (100% specificity) than testing in cerebrospinal fluid (CSF), which has a slightly lower positivity rate (80% vs 74.8%).
- The results suggest that testing for abnormal alpha-synuclein could effectively distinguish iRBD from other types of rapid eye movement sleep disorders, potentially aiding early diagnosis and treatment.
