Spread-out Bragg peak measurements using a compact quality assurance range calorimeter at the Clatterbridge cancer centre.

The superior dose conformity provided by proton therapy relative to conventional x-ray radiotherapy necessitates more rigorous quality assurance (QA) procedures to ensure optimal patient safety. Practically however, time-constraints prevent comprehensive measurements to be made of the proton range in water: a key parameter in ensuring accurate treatment delivery.A novel scintillator-based device for fast, accurate water-equivalent proton range QA measurements for ocular proton therapy is presented.

Excited-State Charge Transfer in Push-Pull Platinum(II) π-Extended Porphyrins Fused with Pentacenequinone.

Platinum(II) π-extended porphyrins fused with pentacenequinone and dihydropentacene have been successfully synthesized. These porphyrins were investigated using various techniques including absorption, steady-state, and time-resolved phosphorescence spectroscopy and differential pulse voltammetry. UV-vis absorption spectra of pentacenequinone-fused porphyrins ( and ) showed unusually broad and nontypical absorption patterns.

Minimal Realization of Light Thermal Dark Matter.

We propose a minimal UV-complete model for kinematically forbidden dark matter (DM) leading to a sub-GeV thermal relic. Our crucial realization is that the two-Higgs-doublet model can provide a light mediator through which the DM can annihilate into standard model leptons, avoiding indirect detection constraints. The DM mass is predicted to be very close to the mass of the leptons, which can potentially be identified from DM annihilation into gamma rays.

Ameliorating hydroxychloroquine induced retinal toxicity through cerium oxide nanoparticle treatments.

The present study investigated the potential protective effects of cerium oxide nanoparticles (CNP) on human retinal pigment epithelium (ARPE-19) cells damaged by hydroxychloroquine (HCQ). Toxicity of HCQ on the ARPE-19 cells was explored with a dose response trial. CNP rescue both a pre-treatment protocol, where CNP were applied 24 hours prior to HCQ application and a simultaneous treatment protocol where both CNP and HCQ were applied together, were used.

Multiple Evanescent White Dot Syndrome Presenting After Initiation of Empagliflozin, a Sodium-Glucose Cotransporter-2 Inhibitor.

Multiple evanescent white dot syndrome (MEWDS) is an inflammatory condition of the retina that typically presents unilaterally with multiple gray-white spots in the outer retina or retinal pigmented epithelium and granular changes within the fovea. We report a case of new-onset MEWDS in a patient closely after the initiation of empagliflozin, a sodium-glucose cotransporter inhibitor medicine for his type II diabetes mellitus.

Current trends in removable partial prosthodontics education in dental colleges of Pakistan.

Objective: The objective of this study was to investigate the current trends in undergraduate teaching of removable partial prosthodontics in various dental colleges of Pakistan.

Methodology: A cross-sectional study was conducted in which a questionnaire was sent by email to head of Prosthodontics department of thirty-one dental institutes of Pakistan. The survey included multiple questions regarding current trends in removable partial prosthodontics education in undergraduate dental colleges.

Late Intraocular Lens Dislocation Resulting From Haptic Breakage Following Cardiopulmonary Resuscitation.

We report a case of an asymptomatic 65-year-old male who on routine eye examination had anterior dislocation of an intraocular lens (IOL) implant placed 23 years prior. Ten months prior to presentation, the patient had cardiac surgery complicated by cardiac arrest requiring chest compressions. Dislocation of an intraocular lens is a rare complication of cataract surgery.

Ceria Nanoparticles Mitigate the Iron Oxidative Toxicity of Human Retinal Pigment Epithelium.

Oxidative injury is implicated in retinal damage observed in age-related macular degeneration (AMD), as well as other degenerative conditions. Abnormally elevated levels of iron accumulation within the retinal pigment epithelium have been detected in eyes with AMD, and it is suspected to play a role in the pathogenesis through the production of reactive oxygen species (ROS). Ceria nanoparticles (CNP) have the ability to scavenge ROS.

Optical Coherence Tomography Angiography Findings in a Case of Cosmetic Laser Induced Retinal Injury.

We report the first known case of iris and retinal injury using optical coherence tomography angiography (OCTA) images following cosmetic laser injury. A 23-year-old female developed left iris and retinal injury post inadvertent firing of a 755 nm Alexandrite cosmetic laser. The patient had no significant past medical history and the injury resulted from inappropriate eye protection during laser use.

Bilateral Superior Altitudinal Hemianopsia with Macular Involvement Confirmed by Multifocal Visual Evoked Potential Testing.

We report a case of bilateral superior altitudinal hemianopsia (BSAH) secondary to pituitary microadenoma related inferior optic chiasm damage. A 69-year-old-female developed a BSAH with macular involvement that was initially considered as malingering due to the obscurity of this symptom. The patient presents with multiple risk factors for ischemic disease to the ocular and occipital vessels, persistent migraine, hypothyroidism, and a stable pituitary microadenoma, yet no evidence of tissue ischemia or infarction was noted on imaging that could account for her visual field defects.

RETOUCH: The Retinal OCT Fluid Detection and Segmentation Benchmark and Challenge.

Retinal swelling due to the accumulation of fluid is associated with the most vision-threatening retinal diseases. Optical coherence tomography (OCT) is the current standard of care in assessing the presence and quantity of retinal fluid and image-guided treatment management. Deep learning methods have made their impact across medical imaging, and many retinal OCT analysis methods have been proposed.

Retinitis Pigmentosa Associated with Glucose-6-Phosphate Dehydrogenase Deficiency.

We report a case of new onset retinitis pigmentosa (RP) associated with a glucose-6-phosphate dehydrogenase (G6PD) deficiency in a 63-year-old African-American male who presented with worsening night vision over a period of five years. The pathogenesis of G6PD-mediated oxidative biological damage is reviewed and a mechanism for the onset of retinal disease proposed.

Bilateral Retinal Detachments Associated with Inversion Table Therapy.

To report a case of sequential bilateral inferior retinal detachments secondary to inversion table therapy. A 67-year-old-male developed inferior rhegmatoegnous retinal detachments (RRD) in both eyes on two different occasions with the use of inversion therapeutic tables. Various predisposing factors have been documented for RRD such as previous cataract surgery, peripheral retinal degenerations, high myopia, history of previous retinal detachments and direct ocular trauma.

Ocular Sarcoidosis Limited to Retinal Vascular Ischemia and Neovascularization.

A 59-year-old Caucasian male experienced progressive vision loss secondary to retinal vascular ischemia and neovascularization. At no time did he present with uveitis or vasculitis, and his serology tests were all negative. He was soon after diagnosed with sarcoidosis by hilar lymph node lung biopsy.

Renal fluid overload diagnosed by retinal optical coherence tomography scanning.

Fluid overload is one of the major findings in patients with end-stage renal disease. Common findings in fluid overload include shortness of breath, pedal edema, ascites, and pericardial effusion. Rarely, vision loss can be associated with decompensated systemic fluid status.

Correction: Retinopathy and Uveitis Associated with Sofosbuvir Therapy for Chronic Hepatitis C Infection.

[This corrects the article DOI: 10.7759/cureus.597.

Combined DSEK and Transconjunctival Pars Plana Vitrectomy.

We report here three patients who underwent combined Descemet's stripping with endothelial keratoplasty and transconjunctival pars plana vitrectomy for bullous keratopathy and posterior segment pathology. A surgical technique and case histories are described. Anatomic and visual outcomes of combined Descemet's stripping with endothelial keratoplasty and vitrectomy were excellent.

Retinopathy and Uveitis Associated with Sofosbuvir Therapy for Chronic Hepatitis C Infection.

Purpose: We report a case of retinopathy and uveitis associated with sofosbuvir therapy for hepatitis C infection.

Methods: Case report.

Results: A 57-year-old-male developed ocular inflammation and retinopathy four weeks after the administration of sofosbuvir for a hepatitis C infection.

Intravitreal Injection-Induced Migraine Headaches.

A case of migraine headache triggered by intravitreal injection, and aborted by retrobulbar injection, is reported. To date, migraine and related cephalgia have not been reported after intravitreal injection. Ophthalmologists and neurologists should be aware of this potential sequela of a very common procedure.

An office-based procedure for hyphema treatment.

Three cases of hyphema in three different eyes were treated in the office using an anterior chamber fluid-gas exchange technique. Hyphemas were associated with complications of underlying systemic and retinal disease and in the postoperative period of vitrectomy procedures. Patients were successfully treated without requiring return to operating room.

In-office use of the intrector for the removal of retained lens cortex.

Purpose: To report a case and technique for the removal of retained lens cortex material in an office-based procedure using a portable battery-powered vitrectomy system.

Methods: Case report.

Results: An 88-year-old man underwent uncomplicated office-based vitrectomy for the removal of retained lens material with good anatomical and visual outcomes.

Telemedicine for retinal care in developing nations: the ORBIS Cyber-Sight programme, 2003-2011.

ORBIS International has provided a web-based ophthalmic disease consultation service, Cyber-Sight, for developing nations since 2003. The system connects partner physicians with mentor physicians. We have reviewed consultations concerning retinal cases submitted from June 2003 to December 2011.

Peristence of triamcinolone crystals after intra-vitreal injection: benign crystalline hyaloidopathy.

We report a case of unusually long persistence of triamcinolone crystals after intra-vitreal injection. Crystals were noted on fundus examination predominantly confined to the posterior pole. Optical coherence tomography localized the crystals to the posterior hyaloidal surface.

Retinal surgery-induced trigeminal neuralgia.

Purpose: To report a case of trigeminal neuralgia after retinal surgery in a 72-year-old man.

Methods: Case report.

Results: A 72-year-old man developed severe postoperative pain after undergoing vitrectomy and endolaser therapy.