Publications by authors named "Saad Alqahtani"

Objectives: The global prevalence of Hashimoto's thyroiditis (HT) and differentiated thyroid cancer (DTC), particularly papillary thyroid cancer (PTC), is increasing. However, studies assessing correlations between these diseases have yielded inconsistent findings. Furthermore, patients diagnosed with HT show a higher prevalence of indeterminate cytology than those without HT.

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Background: The systolic shock index (SSI) is used to direct management and predict outcomes, but its utility in patients requiring rapid response team (RRT) activation is unclear.

Objectives: We explored whether SSI can predict the outcomes of ward patients experiencing clinical deterioration and compared its performance with other parameters.

Methods: This retrospective study included adult patients in medical/surgical wards who required RRT activation.

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Importance: Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness.

Objective: To evaluate the effect of electronic sepsis screening, compared with no screening, on mortality among hospitalized ward patients.

Design, Setting, And Participants: In a stepped-wedge, cluster randomized trial at 5 hospitals in Saudi Arabia, 45 wards (clusters) were randomized into 9 sequences, 5 wards each, to have sepsis screening implemented at 2-month periods.

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Thyroid dysfunction directly affects human health and overall well-being; various approaches are available for the treatment of thyroid diseases, including conservative measures and surgical interventions. Despite advancements in conservative treatment, surgery remains the preferred option. Hypoparathyroidism is the primary cause of hospitalization after thyroidectomy, leading to cost-related concerns and a detrimental impact on patients' overall quality of life.

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Aim: To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) that investigated the effectiveness of tranexamic acid (TXA) among patients undergoing arthroscopic rotator cuff repair (ARCR).

Methods: Five databases were screened until December 18, 2022. The included RCTs were assessed for risk of bias, and the endpoints were summarized as mean difference/standardized mean difference (MD/SMD) or risk ratio (RR) with the 95% confidence interval (CI) in a random-effects model.

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Article Synopsis
  • - The acromiohumeral center-edge angle (ACEA) is linked to a higher risk of rotator cuff tears, as shown by measurements on shoulder radiographs and MRIs.
  • - A study compared ACEA measurements from 45 patients with rotator cuff tears and 41 healthy individuals, revealing significantly higher ACEA values in the tear group on both radiographs and MRIs.
  • - While ACEA measurements on MRI demonstrated strong consistency when measured by the same person (intrarater reliability), they showed inconsistency between different observers (interrater reliability).
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  • Psoriasis is a lifelong skin condition, and Tofacitinib, a type of JAK inhibitor, may help improve skin lesions and overall patient outcomes, but it also carries risks like increased infections due to its immunosuppressive nature.
  • A systematic review and meta-analysis were conducted, following specific guidelines, to compare the safety of Tofacitinib against placebo, focusing on the occurrence of serious infections and other adverse effects among participants.
  • Among 998 studies, only six randomized controlled trials with 2,516 psoriasis patients were included; the results indicated increased risks of herpes zoster and respiratory infections, but no significant differences in safety outcomes were found between those taking Tofacitinib and those receiving a placebo
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Background: Preoperative anxiety is commonly found in patients who are waiting for surgery and can lead to negative surgical outcomes. Understanding the sources of surgical anxiety allows healthcare providers to identify at-risk patients and implement psychosocial interventions such as counseling, relaxation techniques, and cognitive‒behavioral therapy to minimize anxiety. Few comprehensive psychiatric measures are available to assess preoperative anxiety in Arabic.

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Background: Team-based learning (TBL) and problem-based learning (PBL) are two effective educational approaches used in medical education for increasing knowledge acquisition, learning motivation, and collaborative and communication skills among students. Few studies have been conducted in Saudi Arabia to evaluate medical students' perceptions of these approaches.

Aim Of The Study: The present study aimed to evaluate the perceptions of current or previous preclinical students at the College of Medicine, Najran University (NU) about the effectiveness of PBL and TBL and to assess students' perceptions regarding the strengths and limitations of both educational approaches and their preferences.

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Article Synopsis
  • * A review of five studies indicated corticosteroids significantly reduced pain at 24 hours, with some evidence of decreased antibiotic use, but results showed high variability among studies.
  • * While corticosteroids may help lessen pain intensity and duration, the overall evidence is inconclusive due to study limitations, highlighting the need for better-quality randomized controlled trials (RCTs).
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Leiomyoma is defined as a benign proliferation of smooth muscle cells. Smooth muscle tumors are considered the second-most common mesenchymal neoplasm in the gastrointestinal (GI) tract. It typically occurs incidentally in the large bowel.

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Unlabelled:                                                                  Abstract Background: Few studies have addressed the effects of biological therapies on laboratory outcomes and changes in FEV1 in patients with severe asthma (SA) and chronic rhinosinusitis (CRS). We aimed to study the effect of three biological therapies on laboratory outcomes and FEV1 in Saudi Arabian patients with SA and CRS.

Methods: From March to September 2022, a retrospective observational cohort study was undertaken at the severe asthma clinics of the Armed Forces Hospital-Southern Region (AFHSR) and King Khalid University Hospital, Abha, Saudi Arabia, to delineate the effects of 3 biological therapies (benralizumab, dupilumab, and omalizumab) in adults with SA and concomitant CRS in terms of FEV1 and laboratory parameters (serum IgE and eosinophilic counts).

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Article Synopsis
  • Chronic kidney disease-associated pruritus (CKD-aP) is a common and troublesome issue for patients with end-stage renal disease, prompting a study on the effectiveness of omega-3 fatty acid supplementation as a treatment.* -
  • After reviewing multiple research databases, the study found that omega-3 supplementation significantly reduced the severity of CKD-aP and improved symptoms when compared to baseline measurements.* -
  • Despite the promising results, the study acknowledges limitations in the included research and suggests that more high-quality studies are needed to further explore the treatment's effectiveness and reasons for non-responses in some patients.*
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Background: COVID-19 is the largest recorded pandemic in history. It causes several complications such as shock, pneumonia, acute respiratory distress syndrome, and organ failure. The objective was to determine COVID-19 outcomes and risk factors in the intensive care (ICU) setting.

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Background: This study's purposes were to evaluate the impact of biological therapies on outcomes in patients with severe asthma (SA) and chronic rhinosinusitis (CRS) and to compare these effects among those with NP (CRSwNP) versus those without NP (CRSsNP) in the "real-world" setting in Saudi Arabian patients.

Methods: From March to September 2022, a retrospective observational cohort study was undertaken at the severe asthma clinics of the Armed Forces Hospital-Southern Region (AFHSR) and King Khalid University Hospital, Abha, Saudi Arabia, to delineate the effects of dupilumab therapy. Outcomes were assessed, including clinical outcomes, FEV1, and laboratory findings before and one year after dupilumab.

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Aim: Post-operative pain may occur after non-surgical root canal treatment (NSRCT). The root filling technique and choice of sealer may be contributing factors. This randomized controlled clinical trial compared post-operative pain and analgesics intake after NSRCT using a sealer-based obturation technique (SBO) with single-cone gutta-percha and calcium silicate sealer (CSS) versus a warm-vertical compaction (WVC) technique with gutta-percha and a resin-based sealer (RBS).

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Caregivers often use paracetamol in the management of pediatric illnesses without a clear rationale. This study evaluated the perception and practices of caregivers regarding the use of paracetamol in children in Southwestern Saudi Arabia. This study involved a cross-sectional design involving 373 caregivers of children under twelve.

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Background: The association between malignancy risk and nodule size in indeterminate thyroid nodules (ITNs) remains controversial. Thus, we aimed to explore the impact of nodule size as a predictor of cancer in patients with ITNs.

Methods: This cross-sectional study assessed 113 patients who underwent surgical intervention for ITNs, comparing two groups based on nodule size (≥4 or <4 cm).

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Objective: The current research study aimed to access the relationship between obesity and asthma exacerbations and severity among adult patients at the outpatient section of a federal hospital (PIMS) in Islamabad, Pakistan.

Methods: A cross-sectional research study was carried out on 207 asthma adult patients belonging to different areas and ethnic groups from the country. The study setting was the PIMS hospital, which attracts patients from all over the country due to its facilities and cost-effective treatments.

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Article Synopsis
  • Poor solubility of active pharmaceutical ingredients (APIs) is a major challenge in drug efficacy, prompting the development of novel drug delivery systems to enhance solubility and permeability.
  • One notable system, the therapeutic deep eutectic system (THEDES), combines drugs with deep eutectic solvents (DESs) to improve bioavailability, taking advantage of DESs’ non-toxic, biodegradable, and cost-effective properties.
  • This review aims to explore THEDES' composition, formulation strategies, administration routes, and their applications in treating various metabolic and non-metabolic diseases, highlighting their potential in pharmaceutical innovations.
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Background: Managing persistent elbow instability and chronic dislocations presents challenges despite traditional treatments. Supplementary methods like immobilization and various fixations, though common, can carry high complication rates. This study assesses the efficacy of bridge plating in treating complex elbow instability through a retrospective review of patients.

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Background: Benign prostatic hyperplasia (BPH) is a prevalent condition in older men, causing significant morbidity. Despite recent progress, essential concerns of the disease remain under-researched. This study aims to assess knowledge and estimate self-reported prevalence of BPH in Saudi Arabian men.

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Background: Healthcare workers increasingly use Electronic Health Information Resources (EHIRs) to make evidence-based decisions. Our study was intended to assess the perception, attitude, and practice of healthcare professionals in medicine, pharmacy, and nursing regarding their perceived value and use of EHIRs.

Methods: We conducted an observational cross-sectional study using a pre-validated questionnaire among healthcare professionals in Jazan province from September 2022 to February 2023.

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Background: This study aimed to determine the rate of telemedicine (TM) use and the levels of awareness, knowledge, attitude, and skills of TM among primary healthcare (PHC) providers.

Methods: In a cross-sectional study, 104 PHC providers were subjected to a validated AKAS scale via Survey Monkey. The tool consists of 4 parameters that users can respond to using a 4-point Likert scale to assess their awareness (12 statements), knowledge (11 statements), attitude (11 statements), and skills (13 statements) on TM.

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The anatomy of the edentulous posterior maxilla and maxillary sinus possess unique challenges in implant dentistry. The purpose of this study was to assess maxillary sinus membrane thickness (MT) and lateral wall thickness (LWT) in different facial index profiles and to describe the clinical implications. A retrospective image analysis of 75 CBCT scans was done, which yielded a total of 150 sinus images.

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