New dihydrophenanthrenes from .

Three new dihydrophenanthrenes were isolated from the whole plant of collected in Vietnam. These compounds were identified as 2,3,5-trihydroxy-9,10-dihydrophenanthrene (), 2-methoxy-5-hydroxy-9,10-dihydrophenanthrene 3-O--D-glucopyranoside (), and 2,5-dihydroxy-9,10-dihydrophenanthrene 3-O--D-glucopyranoside (). Their structures were determined by HR-ESI-MS and 1D, 2D NMR spectroscopy.

Chemical constituents of Tard. and their -glucosidase inhibition activities.

Sixteen compounds (-) were isolated from . Chemical structures were determined by spectroscopic analyses and comparisons with previously published data. This report is the first to identify compounds , , , , and from the genus Seven chosen isolates (, , , , , , and ) were submitted for -glucosidase inhibition assays with acarbose as the positive control (IC = 227.

New phenolics from (L.) DC.

Reinvestigation of a methanol extract of afforded a new 3- hydroxyisoflavanone, 3,5,7,2',4'-pentahydroxyisoflavanone (), two new monoaryl glucosides, 3,4-dimethoxyphenyl 1--(6'--acetyl)--D-glucopyranoside ( and 3,4,5-trimethoxyphenyl 1--(6'--acetyl)--D-glucopyranoside (), in addition to three known compounds, 3'--methylorobol (), robusflavone B (), and apigenin (). The structural elucidation of these compounds was achieved by analyses of their spectroscopic data (HR-ESI-MS, 1 D- and 2 D-NMR) and acidic hydrolysis. The extracts and compounds - exhibited weak or no cytotoxic activity against KB, HepG2, Lu and MCF7 cell lines.

Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer's disease.

A library of twelve quinazoline-triazole hybrid compounds were designed, synthesized and evaluated as a novel class of acetylcholinesterase inhibitors to treat Alzheimer's disease (AD). The biological assay results demonstrated the ability of several hybrid compounds to inhibit AChE enzyme (IC range = 0.2-83.

Pro-apoptoticeffect of diterpenoids from on acute myeloid leukemia cells.

Previously, we isolated four known diterpenoids, -communic acid (), 13-oxo-15,16-dinor-labda-8(17), 11-diene-19-oic acid (), 3-hydroxytotarol (), and totarolone () from leaves. Further study demonstrated the antiproliferative activity of all four compounds in acute myeloid leukemia (OCI-AML) cells due to impaired cell cycle progression. Interestingly, 3-hydroxytotarol () had very powerful bioactivity at low concentrations (5 µg/mL).

A new isoflavanone from .

A new isoflavanone, (3)-5,7-dihydroxy-2',3',4'-trimethoxy-6,5'-diprenylisoflavanone () and eight known compounds including five flavones (), two triterpenes () and a steroid () were isolated from the whole plant of (Leguminosae). The structure of was elucidated by detailed spectroscopic means including IR, HR-ESI-MS, 1D and 2D NMR, and CD data. Compounds were evaluated for their cytotoxicity against four human cancer cell lines KB (mouth epidermal carcinoma), HepG2 (hepatocellular carcinoma), Lu (lung carcinoma) and MCF7 (breast carcinoma).

A new oleanane triterpene from the leaves of .

Repeated column chromatography of the n-hexane extract of leaves (Moraceae) led to isolation of a new oleanane triterpene, 3-hydroxy-11-oxo-olean-12-enyl-3-stearate () in addition to three known compounds, taraxerol (), 3-acetoxy-11-methoxy-12-ursene () and 3-acetoxy-11-hydroxy-12-ursene (). Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literatures.

Anti-proliferative diterpenes from .

A new diterpene, cassipouryl hexadecanoate (), in addition to the cassipourol () and four terpenes () were isolated from the twigs and leaves of (Blume) de Laub. The structures of the two monocyclic diterpenes (, ), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (, ) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells.

Chemical constituents from the leaves of Pinus dalatensis Ferré.

A phytochemical study of n-hexane and ethyl acetate extracts of Pinus dalatensis Ferré leaves led to the isolation of 11 compounds, including one caryolane sesquiterpenoid (1), five labdane diterpenoids (2, 3, 4, 5, 6), one serratane triterpenoid (7), one diacylated flavonoid glucoside (8), one stilbenoid (9) and two sterols (10, 11). The structural characterisation of the isolated compounds was elucidated by spectroscopic data and comparison with the literature report on the chemical constituents from Pinus dalatensis Ferré. Futhermore, three compounds 1, 4 and 6 were obtained for the first time from the genus Pinus.