Pleural effusion and fibrosis during treatment with methysergide.

Two patients being treated for migraine with methysergide developed extensive pleural fibrosis, and in addition one of them had bilateral pleural effusions, After treatment was stopped these complications, which are thought to have been due to the drug, cleared in the next few months.

A study of 104 cases of migraine.

An inquiry about present or past history of migraine has been made in a factory of 4,700 employees. The incidence of migraine among the 1,607 who replied to a questionnaire was found to be 4·9% for men and 13·2% for women. A family history of migraine was found in migraine sufferers six times more frequently than in non-sufferers, and a personal history of travel sickness was found three times more often in sufferers than non-sufferers.