Local ischemia causes carcinoma-like changes of the rectum.

Purpose: Bioptic specimens of typical cancerous changes in the rectum usually reveal signs of malignancy. Our goal was to describe the clinical feature, histologic findings, and long-term outcome of patients in whom typical findings of carcinoma of the rectum were discovered by endoscopy, but whose histologic data did not confirm the diagnosis of a malignant disease.

Methods: We conducted a retrospective review of eight patients seen in our hospital with a clinical diagnosis of colorectal cancer.

Malignant biliary obstruction: clinical and histopathologic correlation after treatment with self-expanding metal prostheses.

Purpose: To analyze clinical and autopsy findings in patients with malignant biliary obstruction treated with biliary endoprostheses.

Materials And Methods: Stents were inserted endoscopically in nine patients and transhepatically in 50. In 24 patients, autopsy was performed; in 22 cases, histologic analysis of the area in which the stent was placed was available.

[Ischemic ulcer of stomach and duodenum: an unusual cause of a common disease].

Ischemia is a rare cause of gastric and duodenal ulcers. For the present study clinical and anatomo-pathologic data from cases published so far and from twelve own patients with ischemic ulcers have been investigated. Histopathology leads to the diagnosis of an ischemic cause with great accuracy.

Intestinal infarction after nonabdominal trauma; association with cerebral trauma.

Nonocclusive bowel infarction in nonabdominal trauma has been ascribed to periods of hypotension. However, to our knowledge only 17 cases have been reported, and hypotension was not always found. We studied the frequency and possible causes of intestinal infarction in all patients treated at our traumatologic intensive care unit from 1977 through 1986 (n = 2350).

Chemotherapy with MACOP-B and VACOP-B for intermediate- and high-grade non-Hodgkin's lymphoma: clinical results and analysis of prognostic factors.

Eighty-three previously untreated patients with aggressive non-Hodgkin's lymphomas were treated with either MACOP-B (23 patients) or VACOP-B (60 patients) as originally described by Klimo and Conners [1, 2]. Their median age was 46 years. Thirty-seven patients had stage I or II and 46 stage III or IV disease.

[Mycobacterium malmoense infection of the flexor tendon sheath].

Infections of the tendon sheath caused by non-tuberculous mycobacteria are well known. So far, only one case involving Mycobacterium malmoense has been reported. The authors report of a 73-year old patient having undergone carpal tunnel release.

[Angiosarcoma in a mastectomy scar following irradiation].

A 74-year-old patient who had undergone radical mastectomy and postoperative radiotherapy for invasive ductal mammary carcinoma developed an angiosarcoma in the radiotherapy field without associated lymphedema. The latency time was 178 months after the first and 82 months after the second radiotherapy. The total radiation-dose was 54 Gy.

[Risk of malignancies in celiac disease--a retrospective study].

A review of 52 patients with celiac disease showed the development of malignant tumors in eight cases (15%). The following malignomas were diagnosed: one malignant lymphoma, one multiple myeloma, one rhabdomyosarcoma, one carcinoma of the uterus, one carcinoma of the sigmoid colon and three adenocarcinomas of the small bowel. Patients with tumors showed significantly lower hemoglobin, lower serum albumin, and higher sedimentation rates than patients without tumors.

[Adenocarcinoma of the small intestine in celiac disease. Case report and literature review].

We describe three patients with celiac disease complicated by adenocarcinoma of the small intestine, and summarize the 36 cases of this association that have been reported. Retrospectively we found an increased risk (relative risk 25-250) of developing adenocarcinoma of the small intestine in patients with celiac disease in the region of Winterthur (north-east Switzerland). We therefore suggest that celiac disease be considered a premalignant condition not only for malignant lymphoma and gastrointestinal tumors, but also for adenocarcinoma of the small intestine.

[Segmental hemorrhagic colitis following amoxicillin therapy].

We report on three young females complaining of bloody diarrhea of acute onset due to hemorrhagic colitis associated with oral amoxicillin therapy. The bloody diarrhea with abdominal cramps began 4 to 6 days after starting the treatment. Right colon was involved in two patients, and the descending and sigmoid colon in the other.

[Colorectal carcinoma following radiotherapy of gynecological carcinoma].

To assess the risk of radiation-induced cancer of the colon we studied 196 patients with a history of radiation treatment for cancer of the female genital system. After a median follow-up of 12.4 years (range 10-15 years) corresponding to 1172 patient-years, 94 (48%) patients were still alive.

Acute ischaemic colitis in a female long distance runner.

A 34 year old female long distance runner is reported with bloody diarrhoea. Colonoscopy revealed patchy haemorrhagic mucosal lesions throughout the colon. The most extensive lesions were found in the sigmoid colon.

Angiodysplasia of the colon: an expression of occlusive vascular disease.

We performed a prospective case control study and found among 306 patients, in whom a complete colonoscopy was done, 19 patients (6%) with angiodysplasia of the colon. These patients were significantly older than control subjects (p less than 0.05).

[Ischemic-granulomatous colitis: a new differential diagnosis from Crohn's colitis?].

In patients with inflammatory bowel disease the presence of epitheloid cell granuloma is considered to be the most reliable single criterion for the presence of Crohn's disease. We report on 6 patients (5 female, 1 male, mean age 73.5 years) with acute onset of inflammatory bowel disease, in whom the presence of epitheloid cell granuloma led to the diagnosis of Crohn's disease.

[Actinomycosis of the colon: clinical, endoscopic, serological and therapeutic aspects].

The case of a 73-year-old woman with extensive abdominal actinomycosis is reported. It appears to be the first case of abdominal actinomycosis in which endoscopic and serologic investigations have been performed before and after medical therapy. Ultrasonography, CT scan and surgical exploration revealed an extensive inflammatory tumor of the sigmoid colon involving the urinary bladder and uterus.

[Pathology of gastric mucosa polyps].

More frequent use of the endoscope to remove gastric mucosal polyps has also led to better knowledge of the pathology of these polyps. Their classification is still a matter of debate, and hence, by way of introduction, the notions of hyperplastic, hyperplasiogenous and hyperplastic-adenomatous polyp, adenoma, borderline lesion protruded type, foveolar hyperplasia and cysts of the gastric glands are presented. The authors give preference to the WHO classification of 1977.

[Bäfverstedt lymphadenosis benigna cutis. Differential diagnostic delineation from Paget disease].

A case is reported showing differential diagnostic delineation between Paget's disease and Bäfverstedt's disease. Both show single localisation and an eczematoid appearance of the nipple or mamillary area.