Fatal dengue virus infection in an unvaccinated traveler.

Dengue is an increasing threat to individuals living in or visiting endemic countries. Effective vaccines have become available, but their use in travelers is typically only recommended to individuals with documented prior infection. We present a fatal case of severe dengue in an unvaccinated traveler without known prior dengue virus infection but longitudinal serologic and molecular evidence for secondary infection.

Faecal haemoglobin concentration and colorectal cancer site, stage and grade in a symptomatic cohort.

Aim: Minimal evidence exists regarding faecal immunochemical tests (FITs) for colorectal cancer (CRC) site, stage and grade in symptomatic patients. The primary aim is to determine any association between faecal haemoglobin concentration (f-Hb) (analysed with OC-Sensor™ Pledia) and these prognostic factors. The secondary aim is to determine the association between f-Hb and anaemia, microcytosis and iron deficiency (Hb, mean corpuscular volume [MCV] and ferritin).

Fostering inclusive science media: Insights from examining the relationship between women's identities and their anticipated engagement with Deep Look YouTube science videos.

As science media content creators strive for inclusivity in communication design and promotion, they must consider the influence of audiences' identities on their engagement with science media. A gender gap in viewership or "missing audience" has been identified for women viewers for educational science content on digital media; one such example of this is Deep Look, a science video series from KQED public media and PBS Digital Studios distributed on YouTube. This study used a mixed method design (1) to examine women's preferences for Deep Look YouTube video promotions (i.

The epidemiology of odontoid fractures: a study from the Swedish fracture register.

Purpose: The objective of this study is to characterize the occurrence of odontoid fractures within a Swedish population.

Methods: Prospective data of adults diagnosed with an odontoid fracture between 2015 and 2021 were retrieved from the Swedish Fracture Register (SFR). Epidemiologic data including age, sex, injury mechanism, injury type, fracture type (Anderson and D'Alonzo classification), neurological status and treatment type were requested from the SFR.

ClimMob: Software to support experimental citizen science in agriculture.

Experimental citizen science offers new ways to organize on-farm testing of crop varieties and other agronomic options. Its implementation at scale requires software that streamlines the process of experimental design, data collection and analysis, so that different organizations can support trials. This article considers ClimMob software developed to facilitate implementing experimental citizen science in agriculture.

The tricot approach: an agile framework for decentralized on-farm testing supported by citizen science. A retrospective.

Matching crop varieties to their target use context and user preferences is a challenge faced by many plant breeding programs serving smallholder agriculture. Numerous participatory approaches proposed by CGIAR and other research teams over the last four decades have attempted to capture farmers' priorities/preferences and crop variety field performance in representative growing environments through experimental trials with higher external validity. Yet none have overcome the challenges of scalability, data validity and reliability, and difficulties in capturing socio-economic and environmental heterogeneity.

Effectiveness of omalizumab across different dosing regimens in patients with moderate-to-severe allergic asthma.

For patients with moderate-to-severe persistent allergic asthma, omalizumab is approved for subcutaneous administration according to a recommended dosing table based on weight and total immunoglobulin E (IgE) level. The aim of this analysis was to assess asthma outcomes including quality of life in patients with allergic asthma initiated on omalizumab in the PROSPERO trial; patients were stratified by where their IgE and body weight fell on the approved dosing table. Patient groups were defined as Inside Dosing Table: patients whose IgE and weight fell within the approved dosing table (n = 506); Insufficient Data to Recommend a Dose: patients who fell into the section of the approved dosing table where not enough clinical data were available to make dosing recommendations (n = 72); and Outside Dosing Table: patients who fell outside the approved dosing table due to baseline IgE and/or weight (n = 209).

Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases.

Introduction: Drug-induced acute kidney injury (DI-AKI) is a frequent adverse event. The identification of DI-AKI is challenged by competing etiologies, clinical heterogeneity among patients, and a lack of accurate diagnostic tools. Our research aims to describe the clinical characteristics and predictive variables of DI-AKI.

Omalizumab improves sinonasal outcomes in patients with chronic rhinosinusitis with nasal polyps regardless of allergic status.

Background: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have atopic comorbidities, including elevated IgE levels and comorbid asthma. Omalizumab, an IgE monoclonal antibody, is an effective treatment for CRSwNP, but the impact of allergy or asthma status on response to omalizumab in patients with CRSwNP has not been well studied.

Objective: To evaluate the impact of allergy and asthma status on omalizumab treatment in patients with CRSwNP, this posthoc exploratory analysis assessed sinonasal outcomes from subgroups of patients included in POLYP 1 and POLYP 2 and the open-label extension (OLE) trials.

Airway Pressure Release Ventilation in COVID-19-Associated Acute Respiratory Distress Syndrome-A Multicenter Propensity Score-Matched Analysis.

There are limited and partially contradictory data on the effects of airway pressure release ventilation (APRV) in COVID-19-associated acute respiratory distress syndrome (CARDS). Therefore, we analyzed the clinical outcome, complications, and longitudinal course of ventilation parameters and laboratory values in patients with CARDS, who were mechanically ventilated using APRV. Respective data from 4 intensive care units (ICUs) were collected and compared to a matched cohort of patients receiving conventional low tidal volume ventilation (LTV).

Ending the Epidemic: Building Health Care Capacity Through HIV and HCV Preceptorship Programs.

Since 2015, Mount Sinai HIV/HCV Center of Excellence has implemented two-day HIV and HCV preceptorships for New York State health care. Participants assessed their knowledge of and confidence to perform 13 HIV or 10 HCV prevention- and treatment-related skills, measured on a 4-point Likert scale from "not at all" to "very" knowledgeable/confident at baseline, exit survey, and a recent evaluation. Wilcoxon signed rank sum tests determined mean differences at all three time points.

gosset: An R package for analysis and synthesis of ranking data in agricultural experimentation.

To derive insights from data, researchers working on agricultural experiments need appropriate data management and analysis tools. To ensure that workflows are reproducible and can be applied on a routine basis, programmatic tools are needed. Such tools are increasingly necessary for rank-based data, a type of data that is generated in on-farm experimentation and data synthesis exercises, among others.

Disseminated Ureaplasma polyarthritis in a renal transplant recipient.

Background: The risk of infection following kidney transplant increases substantially in the setting of hypogammaglobulinemia and T-cell-depleting therapy. Ureaplasma has been described to cause invasive disease in immunocompromised hosts with humoral immunodeficiency. We describe a kidney transplant recipient with history of antineutrophil cytoplasmic autoantibody (ANCA) vasculitis remotely treated with rituximab who developed Ureaplasma polyarthritis following transplant.

Pregnancy History and Kidney Disease Progression Among Women Enrolled in Cure Glomerulonephropathy.

Introduction: Preeclampsia increases the risk for future chronic kidney disease (CKD). Among those diagnosed with CKD, it is unclear whether a prior history of preeclampsia, or other complications in pregnancy, negatively impact kidney disease progression. In this longitudinal analysis, we assessed kidney disease progression among women with glomerular disease with and without a history of a complicated pregnancy.

Effect of passive solar drying on food security in rural Mozambique.

Achieving food security in Mozambique is critical, since 80% of the population cannot afford an adequate diet. While increasing agricultural production is a necessary effort to address this challenge, inadequate post-harvest treatment leads to storage losses and quality degradation, with repercussions for food security. The use of solar drying is promoted as a solution to provide efficient and reliable access to food preservation that improves the food security situation in rural communities.

Assessing Farmers' Diverse Preferences and Expectations for Tailoring Food and Nutrition Security Interventions in Southeastern Madagascar.

Background: Severe food and nutrition insecurity persists in Madagascar. The Atsimo Atsinanana region is among the most affected areas due to elevated poverty rates and low levels of resilience to frequent shocks. Implementing food and nutrition security (FNS) interventions could help to improve this situation, but to be effective and sustainable, intervention packages must fit the local context.

Improvement of Subjective Olfactory Dysfunction in Chronic Rhinosinusitis With Nasal Polyps After Endoscopic Sinus Surgery.

Objective: Olfactory impairment is a common complaint in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), but the influence of endoscopic sinus surgery (ESS) on olfaction and the factors predicting olfactory impairment are not fully understood. This study aimed to assess the effect of ESS on improving olfactory dysfunction in patients with CRSwNP and to identify factors that predict prognosis.

Methods: A total of 56 patients with CRSwNP reported their self-evaluated olfactory dysfunction score preoperatively and 1 month, 3 months, and 12 months after ESS.

Understanding the drivers of food security among agriculture-based households in Gurué District, Central Mozambique.

Background: The prevalence of food insecurity in Mozambique is alarming, despite progress made during the 2010s. Several studies apply different proxy indicators of food security (FS) to assess the FS situation. However, these studies overlook the factors affecting FS, using only a single data point that results in an incomplete picture of FS.

Lower viral loads in subjects with rhinovirus-challenged allergy despite reduced innate immunity.

Background: Viral infections, especially those caused by rhinovirus, are the most common cause of asthma exacerbations. Previous studies have argued that impaired innate antiviral immunity and, as a consequence, more severe infections contribute to these exacerbations.

Objective: These studies explored the innate immune response in the upper airway of volunteers with allergic rhinitis and asthma in comparison to healthy controls and interrogated how these differences corresponded to severity of infection.