Publications by authors named "SP Chen"

Opsin plays a regulatory role in phototaxis of , functioning as the initial station in the phototransduction cascade. Our study aimed to explore the phototransduction pathway to identify elicitors that may enhance phototaxis in the future. The RNAi technique was employed to inhibit gene expression, followed by RNA-Seq analysis to identify phototransduction genes.

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Background: Migraine is associated with cervical artery dissection (CeAD). Calcitonin gene-related peptide (CGRP) is a multifunctional neuropeptide with vasodilatory effects. The use of anti-CGRP monoclonal antibodies (CGRP mAb) may affect cerebrovascular disease risk; however, no reports have associated CGRP mAb with CeAD.

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This study aimed to investigate the impact of diurnal and seasonal variations in photon flux density (PPFD) and air temperature on PSII efficiency in three sweet potato leaf-color cultivars: green (G), yellow-green (Y), and purple (P). The cultivars were exposed to full sunlight and measurements were taken from November to March. The maximal quantum yield of PSII photochemistry for the dark-adapted state (F/F) indicated Y's increased sensitivity to low temperatures at predawn, followed by G and P.

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Gold coating is prepared by pulse electroplating on zincated aluminum alloys with electroless plated Ni-P and electroplated Ni interlayers under different zincate pretreatment conditions. The quantitative characterization of the bonding strength of coatings on aluminum alloy is conducted by bonding the coating to the face of a loading fixture with E-7 high-strength two-component epoxy adhesive in a tension normal to the bonding interface. The microstructures of coatings on aluminum alloy are investigated by means of scanning electron microscopy, energy disperse spectroscopy and X-ray diffraction.

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Background: Weight control behaviors are commonly observed among adolescents and emerging adults. However, the high prevalence of overweight and obesity in both these age groups remains an imperative health concern. Adolescents and emerging adults represent the most vulnerable groups facing the health burden of obesity.

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Approaches for constructing training sets in genomic selection are proposed to efficiently identify top-performing genotypes from a breeding population. Identifying superior genotypes from a candidate population is a key objective in plant breeding programs. This study evaluates various methods for the training set optimization in genomic selection, with the goal of enhancing efficiency in discovering top-performing genotypes from a breeding population.

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Background: To gain a comprehensive understanding of the altered sensory processing in patients with migraine, in this study, we developed an electroencephalography (EEG) protocol for examining brainstem and cortical responses to sensory stimulation. Furthermore, machine learning techniques were employed to identify neural signatures from evoked brainstem-cortex activation and their interactions, facilitating the identification of the presence and subtype of migraine.

Methods: This study analysed 1,000-epoch-averaged somatosensory evoked responses from 342 participants, comprising 113 healthy controls (HCs), 106 patients with chronic migraine (CM), and 123 patients with episodic migraine (EM).

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  • This study investigates the mitogenomes of two important tree species, Castanopsis carlesii and Castanea henryi, for the first time, highlighting their ecological and economic significance.
  • The research found that C. carlesii's mtDNA has a unique multi-branched structure, while Ca. henryi's mtDNA consists of independent molecules, with the significant variation in their sizes attributed to dispersed repeats.
  • The findings contribute to a better understanding of mitochondrial genome evolution in the Fagaceae family, paving the way for further exploration of key traits such as cell respiration and disease resistance.
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Objectives: Here, we report the distribution of HLA-DPB1 alleles studied in a cohort of 55 randomly collected blood samples from unrelated Taiwanese individuals and the deduced most likely HLA haplotypes associated with the defined DPB1 alleles in the cohort. Our aim is to reveal the unprecedented data on the distribution of HLA-DPB1 alleles in the Taiwanese population and to find out the most probable HLA haplotypes associated with the HLA-DPB1 alleles detected.

Materials And Methods: The material for this study was blood samples, preserved in KEDTA and/or acid citrate dextrose anticoagulants.

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  • - The study aimed to compare the effectiveness of romosozumab (ROMO) and denosumab (DEN) in increasing spine bone mineral density (BMD) in patients using long-term glucocorticoids, specifically those on prednisolone. - Results showed that after 12 months, ROMO significantly increased spine BMD by 7.3% compared to 2.3% with DEN, and this trend continued for both groups at 24 months, although ROMO still had greater gains. - While both treatments were effective, ROMO led to better results for spine BMD, but patients on ROMO reported more injection site reactions.
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  • A study on cluster headaches (CH) found that pre-cluster symptoms (PCSs) occur in 88.7% of patients, often allowing them to predict upcoming headache bouts by an average of 24 hours beforehand.
  • The research categorized 34 different PCSs, with head and neck pain being the most prevalent symptom (81.0%).
  • Additionally, certain PCSs like sleep alterations and cranial autonomic symptoms were linked to better responses to the medication verapamil, suggesting their potential role in treatment strategies.
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Background: Migraine-related perfusion changes are documented but inconsistent across studies due to limited sample size and insufficient phenotyping. The phasic and spatial dynamics across migraine subtypes remains poorly characterized. This study aimed to determine spatiotemporal dynamics of gray matter (GM) perfusion in migraine.

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Introduction: Recent immigrants from racialized minority backgrounds and those who are not proficient in the local language are some of the most vulnerable members of society. Despite having postsecondary educational qualifications and permanent residency status, many are engaged in precarious employment. There is a scarcity of research that has explicitly focused on the work experiences and mental health challenges faced by these immigrants.

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  • In 2020, during the COVID-19 pandemic, many people were stuck at home and feeling really lonely, which made mental health problems worse.
  • The Singapore Art Museum created a program called "Unwind with SAM" that combined looking at art and doing meditation to help people feel better.
  • The report talks about how art and meditation can improve mental health, explains the ideas behind the program, and gives suggestions for others who want to create similar programs in the future.
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Background: There have been limited data on idiopathic intracranial hypertension (IIH) in Asians and there remain uncertainties whether a cerebrospinal fluid (CSF) pressure of 250 mm CSF is an optimum diagnostic cutoff. The aims of the present study included (1) characterization of IIH patients in Taiwan, (2) comparisons among different diagnostic criteria for IIH, and (3) comparisons between patients with CSF pressures of > 250 and 200-250 mm CSF.

Methods: This retrospective study involved IIH patients based on the modified Dandy criteria from two tertiary medical centers in Taiwan.

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  • A study involving 17 patients treated with autologous CAR T cells that target CD7 showed incredible success, with 16 patients achieving minimal residual disease-negative complete remission in less than a month, despite significant leukemia presence.
  • The treatment had mild side effects, and a significant number of patients remained relapse-free, suggesting that anti-CD7 CAR T cell therapy is a promising option for T-ALL.
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  • The study aimed to analyze sex differences in clinical profiles and treatment outcomes of patients with spontaneous intracranial hypotension.
  • Results showed that males had delays in seeking treatment and exhibited fewer symptoms like nausea and tinnitus compared to females, despite similar radiologic findings.
  • Males also had worse treatment responses to epidural blood patches and a higher risk of complications, such as subdural hematoma, indicating the need for tailored management strategies based on sex.
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When Fourier transform (FT) spectrum peaks are overlapped, primary maxima of odd-order derivatives can be used to evaluate their independent intensities. We studied the feasibility of higher odd-order derivatives on Lorentzian peak shape and magnitude peak shape. Simulation studies for FT nuclear magnetic resonance (NMR) spectroscopy demonstrated good results toward quantitative deconvolution of overlapping FT spectrum peaks.

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Reverse electron transfer (RET), an abnormal backward flow of electrons from complexes III/IV to II/I of mitochondria, causes the overproduction of a reduced-type CoQ to boost downstream production of mitochondrial superoxide anions that leads to ischemia-reperfusion injury (IRI) to organs. Herein, we studied low-coordinated gold nanoclusters (AuNCs) with abundant oxygen-binding sites to form an electron-demanding trapper that allowed rapid capture of electrons to compensate for the CoQ/CoQH imbalance during RET. The AuNCs were composed of only eight gold atoms that formed a Cs-symmetrical configuration with all gold atoms exposed on the edge site.

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Background And Purpose: This study aimed to investigate early changes in interstitial fluid (ISF) flow in patients with severe carotid stenosis after carotid angioplasty and stenting (CAS).

Methods: We prospectively recruited participants with carotid stenosis ≥80% undergoing CAS at our institute between October 2019 and March 2023. Magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), and the Mini-Mental State Examination (MMSE) were performed 3 days before CAS.

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Objective: To investigate the expression level of small nucleolar RNA (snoRNA) in bone marrow of patients with acute leukemia (AL) and its significance in the clinical diagnosis, treatment and prognosis of AL patients.

Methods: Bone marrow samples of 53 newly diagnosed AL patients and 29 healthy subjects in the Affiliated Hospital of Guangdong Medical University from March 2018 to December 2021 were collected. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative expression level of in bone marrow mononuclear cells of the two groups.

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  • This study focuses on the genetic factors contributing to vertigo, particularly in Asian populations, as previous research has mostly centered on Europeans.
  • Researchers conducted a large genome-wide association study and identified two significant genomic loci (DROSHA and ZNF91/LINC01224) linked to vertigo, with some findings consistent across different ancestries.
  • Individuals with certain genetic risk factors are 1.74 times more likely to experience vertigo, and the study proposes that these findings could help identify high-risk individuals and enhance understanding of vertigo's underlying mechanisms.
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Integrating structural colors and conductivity into aqueous inks has the potential to revolutionize wearable electronics, providing flexibility, sustainability, and artistic appeal to electronic components. This study aims to introduce bioinspired color engineering to conductive aqueous inks. Our self-assembly approach involves mixing poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) with sulfonic acid-modified polystyrene (sPS) colloids to generate non-iridescent structural colors in the inks.

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